Treatment of a non-healing oral wound in diabetic-induced rats

L. Karalashvili, D. Chakhunashvili, M. Kakabadze, T. Paresishvili, Zurab Kakabadze
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引用次数: 0

Abstract

Aim: Non-healing wounds are one of the most substantial and difficult problems to treat. Wound healing involves a sequence of complex biological processes, but often the oral cavity microbiota adversely affects healing and forms a chronic non-healing wound. Methods: In this study, a biologically active membrane (BAM) is present, consisting of decellularized human amniotic membrane and bone marrow stem cells (BMSCs). The efficacy of BAM was evaluated in a model of non-healing oral wounds in rats with streptozotocin (STZ)-induced diabetes mellitus. Results: Studies have shown that BAM enhanced the healing of chronic oral wounds in animals with induced diabetes mellitus, reduced scarring, and reduced risk of infection. Paracrine freeze-dried BMSCs stimulated angiogenesis and improved wound conditions. Conclusions: BMSCs may lower glucose levels in rats with STZ-induced diabetes mellitus and improve the healing process of chronic diseases. However, more studies are needed to study the paracrine factors of BMSCs and their role in the treatment of non-healing wounds.
治疗糖尿病诱导大鼠口腔不愈合伤口
目的:不愈合的伤口是最实质性和最难治疗的问题之一。伤口愈合涉及一系列复杂的生物过程,但口腔微生物群往往对愈合产生不利影响,形成慢性不愈合的伤口。方法:在本研究中,制备了一种生物活性膜(BAM),由脱细胞人羊膜和骨髓干细胞组成。在链脲佐菌素(STZ)诱导的糖尿病大鼠口腔创伤未愈合模型中评价BAM的疗效。结果:研究表明,BAM促进了糖尿病动物慢性口腔伤口的愈合,减少了瘢痕形成,降低了感染的风险。旁分泌冻干骨髓间充质干细胞刺激血管生成,改善伤口状况。结论:骨髓间充质干细胞可降低stz诱导的糖尿病大鼠的血糖水平,促进慢性疾病的愈合过程。然而,骨髓间充质干细胞的旁分泌因子及其在治疗不愈合伤口中的作用还需要更多的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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