{"title":"Interstitial fluid transport in a multi-compartment model of cerebral blood flow","authors":"Stephen Payne","doi":"10.1093/jom/ufad040","DOIUrl":null,"url":null,"abstract":"\n Whole brain models are a valuable tool to gain a better understanding of cerebral blood flow and metabolism. Recent work has developed multi-compartment models of blood flow and oxygen transport that can be used in a Finite Element framework to simulate whole brain behaviour with low computational expense, helping to move such tools towards clinical application. However, the transport of fluid between the vascular space and the interstitial space has not yet been considered in detail in this context, despite this playing an important role in several cerebrovascular diseases. In this study, an extended framework is proposed to include this transport, coupled with a linear elastic model of tissue displacement to simulate the movement of fluid and the resulting displacement of brain tissue. This framework is compared in detail with previous models. The resulting Eqs. are found to exhibit multiple time scales, and a separation of scales is performed to analyse the behaviour at different time scales. Finally, a simplified model is proposed that can be easily implemented within existing computational frameworks, providing a valuable extension of the pathological conditions that can be simulated.","PeriodicalId":50136,"journal":{"name":"Journal of Mechanics","volume":"52 17","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Mechanics","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1093/jom/ufad040","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MECHANICS","Score":null,"Total":0}
引用次数: 0
Abstract
Whole brain models are a valuable tool to gain a better understanding of cerebral blood flow and metabolism. Recent work has developed multi-compartment models of blood flow and oxygen transport that can be used in a Finite Element framework to simulate whole brain behaviour with low computational expense, helping to move such tools towards clinical application. However, the transport of fluid between the vascular space and the interstitial space has not yet been considered in detail in this context, despite this playing an important role in several cerebrovascular diseases. In this study, an extended framework is proposed to include this transport, coupled with a linear elastic model of tissue displacement to simulate the movement of fluid and the resulting displacement of brain tissue. This framework is compared in detail with previous models. The resulting Eqs. are found to exhibit multiple time scales, and a separation of scales is performed to analyse the behaviour at different time scales. Finally, a simplified model is proposed that can be easily implemented within existing computational frameworks, providing a valuable extension of the pathological conditions that can be simulated.
期刊介绍:
The objective of the Journal of Mechanics is to provide an international forum to foster exchange of ideas among mechanics communities in different parts of world. The Journal of Mechanics publishes original research in all fields of theoretical and applied mechanics. The Journal especially welcomes papers that are related to recent technological advances. The contributions, which may be analytical, experimental or numerical, should be of significance to the progress of mechanics. Papers which are merely illustrations of established principles and procedures will generally not be accepted. Reports that are of technical interest are published as short articles. Review articles are published only by invitation.