{"title":"The Role of Cytokines in the Pathogenesis of Malignant Neoplasms","authors":"V. L. Rybkina, G. V. Adamova, D. S. Oslina","doi":"10.1134/s1990519x23060111","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>This paper analyzes the literature data on the role of cytokines in the pathogenesis of malignant neoplasms. Cytokines are biologically active, hormone-like proteins that regulate a wide range of processes occurring in the body. Cytokines determine the type and duration of the immune response, stimulation or suppression of cell growth, and their differentiation and functional activity. The complex of cytokines produced in the tumor microenvironment play an important role in the pathogenesis of malignant neoplasms. The spectra of biological activities of cytokines in most cases overlap. The same process in a cell can be stimulated by more than one cytokine, creating a favorable environment for the initiation and progression of cancer. The immune system can recognize transformed cells. Various cytokines correspond to specific pathways activated by receptors on the cell surface, which, in turn, induce intracellular signaling cascades that affect targeted cellular functions. Cytokine genes are mutually associated with oncogenes. Cytokines that are released in response to infection or inflammation or in the course of an immune response to an antigen can suppress tumor development. In turn, cytokines that attenuate apoptosis and promote invasion and metastasis promote tumor growth. Cytokines are involved in the initiation, development, and metastasis of malignant neoplasms through various mechanisms.</p>","PeriodicalId":9705,"journal":{"name":"Cell and Tissue Biology","volume":"99 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell and Tissue Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s1990519x23060111","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
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Abstract
This paper analyzes the literature data on the role of cytokines in the pathogenesis of malignant neoplasms. Cytokines are biologically active, hormone-like proteins that regulate a wide range of processes occurring in the body. Cytokines determine the type and duration of the immune response, stimulation or suppression of cell growth, and their differentiation and functional activity. The complex of cytokines produced in the tumor microenvironment play an important role in the pathogenesis of malignant neoplasms. The spectra of biological activities of cytokines in most cases overlap. The same process in a cell can be stimulated by more than one cytokine, creating a favorable environment for the initiation and progression of cancer. The immune system can recognize transformed cells. Various cytokines correspond to specific pathways activated by receptors on the cell surface, which, in turn, induce intracellular signaling cascades that affect targeted cellular functions. Cytokine genes are mutually associated with oncogenes. Cytokines that are released in response to infection or inflammation or in the course of an immune response to an antigen can suppress tumor development. In turn, cytokines that attenuate apoptosis and promote invasion and metastasis promote tumor growth. Cytokines are involved in the initiation, development, and metastasis of malignant neoplasms through various mechanisms.
期刊介绍：
The journal publishes papers on vast aspects of cell research, including morphology, biochemistry, biophysics, genetics, molecular biology, immunology. The journal accepts original experimental studies, theoretical articles suggesting novel principles and approaches, presentations of new hypotheses, reviews highlighting major developments in cell biology, discussions. The main objective of the journal is to provide a competent representation and integration of research made on cells (animal and plant cells, both in vivo and in cell culture) offering insight into the structure and functions of live cells as a whole. Characteristically, the journal publishes articles on biology of free-living and parasitic protists, which, unlike Metazoa, are eukaryotic organisms at the cellular level of organization.
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