Distinguishing Between Linear and Nonlinear (Cooperative) Mechanisms of Substrate Activation Under “Ligand- and Copper-Free” Conditions of the Sonogashira Reaction
E. V. Larina, A. A. Kurokhtina, N. A. Lagoda, A. F. Schmidt
{"title":"Distinguishing Between Linear and Nonlinear (Cooperative) Mechanisms of Substrate Activation Under “Ligand- and Copper-Free” Conditions of the Sonogashira Reaction","authors":"E. V. Larina, A. A. Kurokhtina, N. A. Lagoda, A. F. Schmidt","doi":"10.1134/S0023158423060095","DOIUrl":null,"url":null,"abstract":"<p>A comparative study was made of the differential selectivity of the Sonogashira reaction with a pair of competing arylacetylenes under “ligand- and copper-free” conditions by varying nature and concentration of aryl halides and bases common to competing substrates. The change in the differential selectivity with varying nature of aryl halides is consistent with the proposal that aryl halide and arylacetylene are activated sequentially according to a mechanism that is linear in terms of chemical kinetics. The observed lack of influence of the nature and concentration of the base on the selectivity of the reaction under competition between arylacetylenes indicates that the step of their activation is virtually irreversible.</p>","PeriodicalId":682,"journal":{"name":"Kinetics and Catalysis","volume":"64 6","pages":"793 - 803"},"PeriodicalIF":1.3000,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kinetics and Catalysis","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S0023158423060095","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
A comparative study was made of the differential selectivity of the Sonogashira reaction with a pair of competing arylacetylenes under “ligand- and copper-free” conditions by varying nature and concentration of aryl halides and bases common to competing substrates. The change in the differential selectivity with varying nature of aryl halides is consistent with the proposal that aryl halide and arylacetylene are activated sequentially according to a mechanism that is linear in terms of chemical kinetics. The observed lack of influence of the nature and concentration of the base on the selectivity of the reaction under competition between arylacetylenes indicates that the step of their activation is virtually irreversible.
期刊介绍：
Kinetics and Catalysis Russian is a periodical that publishes theoretical and experimental works on homogeneous and heterogeneous kinetics and catalysis. Other topics include the mechanism and kinetics of noncatalytic processes in gaseous, liquid, and solid phases, quantum chemical calculations in kinetics and catalysis, methods of studying catalytic processes and catalysts, the chemistry of catalysts and adsorbent surfaces, the structure and physicochemical properties of catalysts, preparation and poisoning of catalysts, macrokinetics, and computer simulations in catalysis. The journal also publishes review articles on contemporary problems in kinetics and catalysis. The journal welcomes manuscripts from all countries in the English or Russian language.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
