Comparing the survival rates of patients with stage IIIC endometrial cancer undergoing sandwich therapy to those undergoing sequential chemotherapy and radiotherapy: a meta-analysis

Meng-Meng Zhang, Yu-Kun Chen, Li Shi, Jing Ma, Jing-De Jia, Xi-Wa Zhao
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Abstract

Background

The use of additional treatment after surgery for stage IIIC endometrial cancer (EC) according to the Federation of Gynecology and Obstetrics (FIGO) is still a topic of discussion. This meta-analysis examined the effects of sandwich treatment and sequential treatment on the survival of individuals diagnosed with stage IIIC EC.

Methods

We examined the literature from various databases regarding the overall survival (OS) and adverse effects of the two additional therapies following surgery in individuals diagnosed with stage IIIC EC. Revman 5.4.1 was utilized to combine hazard ratios (HR) and their corresponding 95% confidence intervals (95% CI) for OS and toxicities.

Results

The findings comprised of five retrospective investigations involving a combined total of 800 individuals. The patients who underwent sandwich treatment did not demonstrate a notable improvement in survival rates over a period of 3 years. Upon eliminating the impact of extensive samples, it was discovered that sandwich therapy exhibited a superior 5-year overall survival compared to patients receiving sequential therapy. The effectiveness of sandwich therapy was superior to sequential therapy in terms of a 3-year OS for non-endometrioid histology, although the outcome did not reach statistical significance. The toxicities of both treatments were similar.

Conclusions

In terms of long-term survival, sandwich therapy was found to be more advantageous than sequential therapy for patients with stage IIIC EC, with no significant disparity observed in the 3-year OS and toxicities between the two treatments. Sandwich therapy exhibited a tendency towards improved effectiveness in patients with histology other than endometrioid.

Abstract Image

比较接受三明治疗法和连续化疗及放疗的 IIIC 期子宫内膜癌患者的生存率:一项荟萃分析
背景根据妇产科联盟(FIGO)的规定,IIIC期子宫内膜癌(EC)手术后使用额外治疗仍是一个讨论话题。这项荟萃分析研究了夹心治疗和序贯治疗对确诊为IIIC期EC患者生存期的影响。方法我们研究了各种数据库中关于确诊为IIIC期EC患者术后两种额外疗法的总生存期(OS)和不良反应的文献。结果研究结果包括五项回顾性调查,共涉及 800 名患者。接受三明治治疗的患者在3年内的生存率没有明显改善。在剔除大量样本的影响后,发现三明治疗法的 5 年总生存率优于接受连续疗法的患者。就非子宫内膜样组织学而言,三明治疗法的3年生存率优于序贯疗法,但结果未达到统计学意义。结论 对于IIIC期EC患者,就长期生存率而言,三明治疗法比序贯疗法更有优势,两种疗法的3年生存率和毒性均无明显差异。夹心疗法对子宫内膜异位症以外组织学的患者有改善疗效的趋势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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