Higher Mediterranean diet score is associated with longer time between relapses in Australian females with multiple sclerosis

arXiv - QuanBio - Other Quantitative Biology Pub Date : 2023-11-02 DOI:arxiv-2311.01042

Hajar Mazahery, Alison Daly, Ngoc Minh Pham, Madeleine Stephens, Eleanor Dunlop, Anne-Louise Ponsonby, Ausimmune/AusLong Investigator Group, Lucinda J Black

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Abstract

A higher Mediterranean diet score has been associated with lower likelihood of multiple sclerosis. However, evidence regarding its association with disease activity and progression is limited. Using data from the AusLong Study, we tested longitudinal associations (over 10 years follow-up) between the alternate Mediterranean diet score (aMED) and aMED-Red (including moderate consumption of unprocessed red meat) and time between relapses and disability measured by Expanded Disability Status Scale (EDSS) (n=132; 27 males, 105 females). We used covariate-adjusted survival analysis for time between relapses, and time series mixed-effects negative binomial regression for EDSS. After adjusting for covariates, both higher aMED (aHR=0.94, 95%CI: 0.90, 0.99, p=0.009) and higher aMED-Red (aHR=0.93, 95%CI: 0.89, 0.97, p=0.001) were associated with significantly longer time between relapses in females. Whether specific dietary components of a Mediterranean diet are important in relation to relapses merits further study.

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在澳大利亚多发性硬化症女性患者中，地中海饮食评分越高，复发间隔时间越长

地中海饮食得分越高，患多发性硬化症的可能性越低。然而，关于其与疾病活动性和进展的关联的证据有限。使用来自AusLong研究的数据，我们测试了替代地中海饮食评分(aMED)和aMED- red(包括适度食用未加工的红肉)之间的纵向关联(超过10年的随访)，以及通过扩展残疾状态量表(EDSS)测量的复发和残疾之间的时间(n=132;男性27人，女性105人)。我们使用协变量调整生存分析来分析复发间隔时间，并使用时间序列混合效应负二项回归来分析EDSS。校正协变量后，较高的aMED (aHR=0.94, 95%CI: 0.90, 0.99,p=0.009)和较高的aMED- red (aHR=0.93, 95%CI: 0.89, 0.97, p=0.001)与女性复发间隔时间显著延长相关。地中海饮食的特定饮食成分是否与复发有重要关系值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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arXiv - QuanBio - Other Quantitative Biology

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