Potential therapeutic targets for Membranous Nephropathy: proteome-wide Mendelian randomization and colocalization analysis

Zhihang Su, Qijun Wan
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Abstract

Background The currently available medications for treating membranous nephropathy (MN) still have unsatisfactory efficacy in inhibiting disease recurrence, slowing down its progression, and even halting the development of end-stage renal disease. There is still a need to develop novel drugs targeting MN.
膜性肾病的潜在治疗靶点:全蛋白质组孟德尔随机化和共定位分析
背景目前可用的治疗膜性肾病(MN)的药物在抑制疾病复发、减缓其进展、甚至阻止终末期肾脏疾病发展方面的疗效仍不理想。目前仍需要开发针对MN的新型药物。
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