Mass Spectrometry-Based Proteomic Profiling of Sonicate Fluid Differentiates Staphylococcus aureus Periprosthetic Joint Infection from Non-Infectious Failure: A pilot study

medRxiv - Orthopedics Pub Date : 2022-12-30 DOI:10.1101/2022.12.28.22284010

Cody R. Fisher, Kiran K. Mangalaparthi, Kerryl E. Greenwood-Quaintance, Matthew P. Abdel, Akhilesh Pandey, Robin Patel

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Abstract

Purpose This study aims to use proteomic profiling of sonicate fluid samples to compare host response during Staphylococcus aureus-associated periprosthetic joint infection (PJI) and non-infected arthroplasty failure (NIAF) and investigate novel biomarkers to increase diagnostic accuracy.

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基于质谱的超声流体蛋白质组学分析区分假体周围金黄色葡萄球菌感染和非感染性失败:一项初步研究

本研究旨在利用超声液样本的蛋白质组学分析来比较金黄色葡萄球菌相关假体周围关节感染(PJI)和非感染性关节置换术失败(NIAF)期间的宿主反应，并研究新的生物标志物以提高诊断准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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medRxiv - Orthopedics

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