Mathematical modeling of vaporization during laser-induced thermotherapy in liver tissue

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-06-03 DOI:10.1186/s13362-020-00082-4

Sebastian Blauth, Frank Hübner, Christian Leithäuser, Norbert Siedow, Thomas J. Vogl

引用次数: 8

Abstract

Laser-induced thermotherapy (LITT) is a minimally invasive method causing tumor destruction due to heat ablation and coagulative effects. Computer simulations can play an important role to assist physicians with the planning and monitoring of the treatment. Our recent study with ex-vivo porcine livers has shown that the vaporization of the water in the tissue must be taken into account when modeling LITT. We extend the model used for simulating LITT to account for vaporization using two different approaches. Results obtained with these new models are then compared with the measurements from the original study.

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肝组织激光热疗过程中汽化的数学建模

激光热疗(Laser-induced thermal therapy, LITT)是一种利用热消融和凝固作用破坏肿瘤的微创治疗方法。计算机模拟可以发挥重要作用，协助医生与计划和监测治疗。我们最近对离体猪肝的研究表明，在建立LITT模型时必须考虑组织中水的蒸发。我们扩展了用于模拟LITT的模型，以使用两种不同的方法来考虑汽化。然后将这些新模型得到的结果与原始研究的测量结果进行比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.