Nanoparticle therapy for antibiotic-resistant bacteria: current methods and prospects

IF 1.3 4区工程技术 Q4 ENGINEERING, BIOMEDICAL

Bioinspired Biomimetic and Nanobiomaterials Pub Date : 2023-11-23 DOI:10.1680/jbibn.22.00056

Tigabu M Bekele, Getachew A Alamnie, Abayneh Girma, Gedefaw B Mebratie

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引用次数: 0

Abstract

Emerging diseases due to antibiotic-resistant bacteria cause severe health concerns while increasing their negative effects on human health. The overuse or misuse of antimicrobial agents has contributed to the evolution of bacterial resistance to current medications. Bacteria can develop resistance by altering drugs, changing their target sites, forming biofilms and spending more time in the intracellular environment. Due to this, efforts are being made to create novel, alternative nanoantibiotics as a promising strategy to treat bacteria that cause disease and have developed resistance to a variety of drugs. Utilizing their biocidal properties, nanoparticles can be directed for medication delivery to particular tissues and employed as antibacterial agents against a range of illnesses. Targeted medication delivery-related toxicity problems may be solved with the aid of nanoencapsulation technology. This review paper generally provides a conceptual foundation for understanding the complexity of the problem of the development of antibiotic-resistant bacteria, particularly for brand-new synthetic antibiotics. This information will allow researchers to explore the use of nanoparticles in the treatment of multidrug-resistant bacteria.

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纳米颗粒治疗耐药细菌:目前的方法和前景

由于耐抗生素细菌引起的新出现的疾病引起严重的健康问题，同时增加了它们对人类健康的负面影响。过度使用或误用抗菌药物导致细菌对当前药物产生耐药性。细菌可以通过改变药物、改变靶点、形成生物膜和在细胞内环境中停留更长时间来产生耐药性。正因为如此，人们正在努力创造新的、可替代的纳米抗生素，作为一种有希望的策略来治疗引起疾病并对多种药物产生耐药性的细菌。利用其生物杀灭特性，纳米颗粒可以直接用于将药物输送到特定组织，并用作对抗一系列疾病的抗菌剂。纳米胶囊化技术可以解决靶向给药相关的毒性问题。这篇综述为理解耐药细菌，特别是新型合成抗生素发展问题的复杂性提供了基本的概念基础。这一信息将使研究人员能够探索纳米颗粒在治疗耐多药细菌中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioinspired Biomimetic and Nanobiomaterials ENGINEERING, BIOMEDICAL-MATERIALS SCIENCE, BIOMATERIALS

CiteScore

2.20

自引率

0.00%

发文量

期刊介绍： Bioinspired, biomimetic and nanobiomaterials are emerging as the most promising area of research within the area of biological materials science and engineering. The technological significance of this area is immense for applications as diverse as tissue engineering and drug delivery biosystems to biomimicked sensors and optical devices. Bioinspired, Biomimetic and Nanobiomaterials provides a unique scholarly forum for discussion and reporting of structure sensitive functional properties of nature inspired materials.