What is a Bladder Cancer Molecular Subtype? – Counterpoint

IF 1 4区医学 Q4 ONCOLOGY

Bladder Cancer Pub Date : 2023-11-10 DOI:10.3233/blc-230059

François Radvanyi, Francisco X. Real, David McConkey

引用次数: 0

Abstract

In an accompanying paper, Mattias Hoglund discusses on what is a bladder cancer molecular subtype. He emphasizes the need to consider the aim of tumor classification, which is obviously critical to the approach. He also focuses on considering primarily the identity features of the neoplastic cells. Here, we provide a counterpoint. While largely agreeing with his views, we underline that other parameters that may vary in a spatial or temporal scale, and the tumor microenvironment, can also provide relevant information to render tumor classifications clinically useful. Furthermore, tumor heterogeneity and evolution during the disease course - natural or under therapeutic pressure - should be considered.

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什么是膀胱癌分子亚型?——对位

在一篇相关论文中，Mattias Hoglund讨论了什么是膀胱癌分子亚型。他强调需要考虑肿瘤分类的目的，这显然对该方法至关重要。他还着重考虑肿瘤细胞的主要特征。在这里，我们提供了一个对应物。虽然在很大程度上同意他的观点，但我们强调，其他可能在空间或时间尺度上变化的参数，以及肿瘤微环境，也可以提供相关信息，使肿瘤分类在临床上有用。此外，肿瘤的异质性和疾病过程中的演变-自然或在治疗压力下-应考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bladder Cancer Medicine-Urology

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： Bladder Cancer is an international multidisciplinary journal to facilitate progress in understanding the epidemiology/etiology, genetics, molecular correlates, pathogenesis, pharmacology, ethics, patient advocacy and survivorship, diagnosis and treatment of tumors of the bladder and upper urinary tract. The journal publishes research reports, reviews, short communications, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that expedites our fundamental understanding and improves treatment of tumors of the bladder and upper urinary tract.