Purple grape juice improves performance of recreational runners, but the effect is genotype dependent: a double blind, randomized, controlled trial

IF 3.5 3区医学 Q1 Medicine

Genes and Nutrition Pub Date : 2022-06-02 DOI:10.1186/s12263-022-00710-1

de Sousa, Bruno Rafael Virginio, de Lima Tavares Toscano, Lydiane, de Almeida Filho, Eder Jackson Bezerra, Sena, Klécia Farias, Costa, Matheus Silveira, de Souza Cunha, Rebeka Correia, de Souza Siqueira Quintans, Jullyana, Heimfarth, Luana, Marques, Aline Telles Biasoto, da Silva, Darcilene Fiuza, de Campos, Luis Felipe Castelli Correia, Persuhn, Darlene Camati, Silva, Alexandre Sérgio

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引用次数: 1

Abstract

We examined the influence of superoxide dismutase 3 (SOD3) Arg213Gly and Peroxisome Proliferator-Activated α-Receptor (PPARα) 7G/C polymorphisms to a single dose of purple grape juice supplementation on time-to-exhaustion running test, redox balance and muscle damage in recreational runners. Forty-seven male recreational runners performed a running test until exhaustion after supplementation with grape juice or a control drink. Serum total antioxidant capacity (TAC), malondialdehyde (MDA), plasma nitrite (NO), creatine kinase (CK) and lactate dehydrogenase (LDH) were measured pre and post exercise. Also, polymorphisms were analyzed in DNA extracted from the oral mucosa. Grape juice improved the time-to-exhaustion. When analyzed by genotype, the recreational runners with GG+CG genotypes of the SOD3 gene had greater time-to-exhaustion than the CC genotype, but was no different for the PAPRα gene. A slight difference was noted in TAC, since the CC genotype of the SOD3 gene showed higher TAC values in the post-exercise compared to the baseline and with pre-exercise, but these values did not increase compared to the CG+GG group, respectively. The SOD3 and PPARα genes were similar at all times for the other biochemical variables. The ergogenic effect of grape juice was genotype-dependent for SOD3 Arg213Gly. However, biochemical redox balance markers did not explain this difference.

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紫葡萄汁可以提高休闲跑步者的表现，但效果是基因型依赖的:一项双盲、随机、对照试验

我们研究了单剂量紫葡萄汁对超氧化物歧化酶3 (SOD3) Arg213Gly和过氧化物酶体增殖物激活α-受体(PPARα) 7G/C多态性对休闲跑步者疲劳时间测试、氧化还原平衡和肌肉损伤的影响。47名男性休闲跑步者在补充葡萄汁或对照饮料后进行了跑步测试，直到筋疲力尽。测定运动前后血清总抗氧化能力(TAC)、丙二醛(MDA)、血浆亚硝酸盐(NO)、肌酸激酶(CK)和乳酸脱氢酶(LDH)。同时，对口腔黏膜提取的DNA进行多态性分析。葡萄汁缩短了疲劳时间。通过基因型分析，SOD3基因GG+CG基因型的休闲跑步者比CC基因型的跑步者有更长的疲劳时间，但PAPRα基因没有差异。TAC略有差异，因为SOD3基因的CC基因型在运动后与基线和运动前相比显示更高的TAC值，但这些值分别与CG+GG组相比没有增加。SOD3和PPARα基因在其他生化变量中始终相似。葡萄汁对SOD3 Arg213Gly的基因型依赖性。然而，生化氧化还原平衡标志物并不能解释这种差异。

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来源期刊

Genes and Nutrition Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

7.90

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： This journal examines the relationship between genetics and nutrition, with the ultimate goal of improving human health. It publishes original research articles and review articles on preclinical research data coming largely from animal, cell culture and other experimental models as well as critical evaluations of human experimental data to help deliver products with medically proven use.