de Sousa, Bruno Rafael Virginio, de Lima Tavares Toscano, Lydiane, de Almeida Filho, Eder Jackson Bezerra, Sena, Klécia Farias, Costa, Matheus Silveira, de Souza Cunha, Rebeka Correia, de Souza Siqueira Quintans, Jullyana, Heimfarth, Luana, Marques, Aline Telles Biasoto, da Silva, Darcilene Fiuza, de Campos, Luis Felipe Castelli Correia, Persuhn, Darlene Camati, Silva, Alexandre Sérgio
{"title":"Purple grape juice improves performance of recreational runners, but the effect is genotype dependent: a double blind, randomized, controlled trial","authors":"de Sousa, Bruno Rafael Virginio, de Lima Tavares Toscano, Lydiane, de Almeida Filho, Eder Jackson Bezerra, Sena, Klécia Farias, Costa, Matheus Silveira, de Souza Cunha, Rebeka Correia, de Souza Siqueira Quintans, Jullyana, Heimfarth, Luana, Marques, Aline Telles Biasoto, da Silva, Darcilene Fiuza, de Campos, Luis Felipe Castelli Correia, Persuhn, Darlene Camati, Silva, Alexandre Sérgio","doi":"10.1186/s12263-022-00710-1","DOIUrl":null,"url":null,"abstract":"We examined the influence of superoxide dismutase 3 (SOD3) Arg213Gly and Peroxisome Proliferator-Activated α-Receptor (PPARα) 7G/C polymorphisms to a single dose of purple grape juice supplementation on time-to-exhaustion running test, redox balance and muscle damage in recreational runners. Forty-seven male recreational runners performed a running test until exhaustion after supplementation with grape juice or a control drink. Serum total antioxidant capacity (TAC), malondialdehyde (MDA), plasma nitrite (NO), creatine kinase (CK) and lactate dehydrogenase (LDH) were measured pre and post exercise. Also, polymorphisms were analyzed in DNA extracted from the oral mucosa. Grape juice improved the time-to-exhaustion. When analyzed by genotype, the recreational runners with GG+CG genotypes of the SOD3 gene had greater time-to-exhaustion than the CC genotype, but was no different for the PAPRα gene. A slight difference was noted in TAC, since the CC genotype of the SOD3 gene showed higher TAC values in the post-exercise compared to the baseline and with pre-exercise, but these values did not increase compared to the CG+GG group, respectively. The SOD3 and PPARα genes were similar at all times for the other biochemical variables. The ergogenic effect of grape juice was genotype-dependent for SOD3 Arg213Gly. However, biochemical redox balance markers did not explain this difference.","PeriodicalId":54337,"journal":{"name":"Genes and Nutrition","volume":"1 1","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genes and Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12263-022-00710-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 1
Abstract
We examined the influence of superoxide dismutase 3 (SOD3) Arg213Gly and Peroxisome Proliferator-Activated α-Receptor (PPARα) 7G/C polymorphisms to a single dose of purple grape juice supplementation on time-to-exhaustion running test, redox balance and muscle damage in recreational runners. Forty-seven male recreational runners performed a running test until exhaustion after supplementation with grape juice or a control drink. Serum total antioxidant capacity (TAC), malondialdehyde (MDA), plasma nitrite (NO), creatine kinase (CK) and lactate dehydrogenase (LDH) were measured pre and post exercise. Also, polymorphisms were analyzed in DNA extracted from the oral mucosa. Grape juice improved the time-to-exhaustion. When analyzed by genotype, the recreational runners with GG+CG genotypes of the SOD3 gene had greater time-to-exhaustion than the CC genotype, but was no different for the PAPRα gene. A slight difference was noted in TAC, since the CC genotype of the SOD3 gene showed higher TAC values in the post-exercise compared to the baseline and with pre-exercise, but these values did not increase compared to the CG+GG group, respectively. The SOD3 and PPARα genes were similar at all times for the other biochemical variables. The ergogenic effect of grape juice was genotype-dependent for SOD3 Arg213Gly. However, biochemical redox balance markers did not explain this difference.
期刊介绍:
This journal examines the relationship between genetics and nutrition, with the ultimate goal of improving human health. It publishes original research articles and review articles on preclinical research data coming largely from animal, cell culture and other experimental models as well as critical evaluations of human experimental data to help deliver products with medically proven use.