Is shrunken pore syndrome also a reality in children?

IF 9 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Journal of Internal Medicine Pub Date : 2023-12-06 DOI:10.1111/joim.13749

Mathilde Roussel, Justine Bacchetta, Anne Laure Sellier-Leclerc, Sandrine Lemoine, Aurélie De Mul, Laurence Derain Dubourg

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引用次数: 0

Abstract

Background

Shrunken pore syndrome (SPS) is defined as cystatin C-based-eGFR (eGFRcys)/creatinine-based-eGFR (eGFRcreat) <0.6 or 0.7 and is associated with an increased cardiovascular risk. SPS has been described in children, but no link to increased morbi-mortality was demonstrated.

Objectives

Study the prevalence of SPS in a pediatric population using several glomerular filtration rate (GFR) estimating formulas and measured GFR and evaluate the potential link with cardiovascular risk.

Methods

In 307 renal risk pediatric patients, we studied prevalence of SPS either with CKiDU25creat and cyst or with FAScreat and cyst and EKFCcreat. The characteristics of patients with SPS (defined with Full-age spectrum equation (FAS) and/or European Kidney Function Consortium equation (EKFC)) were compared.

Results and conclusion

The prevalence of SPS varies widely depending on the threshold and the formulas used. Higher C-reactive protein (CRP) and phosphate levels and smaller size are observed in children with SPS defined with FAS and/or EKFC and might be associated with long-term increased cardiovascular risk. Further studies in wider general pediatric populations are warranted.

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毛孔萎缩综合症在儿童中也存在吗?

背景:毛孔萎缩综合征(SPS)被定义为以胱抑素c为基础的egfr (eGFRcys)/以肌酐为基础的egfr (eGFRcreat)。目的:利用几种肾小球滤过率(GFR)估算公式和测量的GFR，研究SPS在儿科人群中的患病率，并评估其与心血管风险的潜在联系。方法:在307例肾危险儿童中，我们研究了CKiDU25creat合并囊肿或FAScreat合并囊肿合并EKFCcreat的SPS患病率。比较SPS患者(用全年龄谱方程(FAS)和/或欧洲肾功能联盟方程(EKFC)定义)的特征。结果与结论:SPS的患病率因阈值和使用的配方不同而有很大差异。在FAS和/或EKFC定义为SPS的儿童中，观察到较高的c反应蛋白(CRP)和磷酸盐水平以及较小的尺寸，这可能与长期心血管风险增加有关。有必要在更广泛的普通儿科人群中进行进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Internal Medicine 医学-医学：内科

CiteScore

22.00

自引率

0.90%

发文量

176

审稿时长

4-8 weeks

期刊介绍： JIM – The Journal of Internal Medicine, in continuous publication since 1863, is an international, peer-reviewed scientific journal. It publishes original work in clinical science, spanning from bench to bedside, encompassing a wide range of internal medicine and its subspecialties. JIM showcases original articles, reviews, brief reports, and research letters in the field of internal medicine.