Asbestos Exposure and Ovarian Cancer: A Meta-analysis

IF 3.5 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Safety and Health at Work Pub Date : 2024-03-01 DOI:10.1016/j.shaw.2023.11.002

Seo Young Kim , Ha Kyun Chang , Ohwi Kwon , JaeYoung Park , Jun-Pyo Myong

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引用次数: 0

Abstract

Background

The International Agency for Research on Cancer (IARC) Monograph conducted a systematic review of the relationship between asbestos and ovarian cancer. However, there may have been information bias due to the undue weight given to few articles. To address this limitation, the present study performed a meta-analysis integrating studies published both before and after the 2012 IARC Monograph on Asbestos, with the aim of investigating the association between asbestos exposure and ovarian cancer.

Methods

A comprehensive search of major journal databases was conducted to identify studies examining the relationship between asbestos exposure and ovarian cancer, including those featured in the 2012 IARC Monograph on Asbestos. A meta-analysis on asbestos exposure and cancer risk was performed.

Results

The meta-analysis of studies published after the 2012 IARC Monograph on Asbestos found a summary Standardized Mortality Ratio (SMR) of 2.04 (95% CI: 1.03—4.05; p = 0.0123; 5 studies), with a significant degree of heterogeneity among the studies (I² = 72.99%). The combined analysis of 15 studies before and after the 2012 IARC Monograph showed an overall summary SMR of 1.72 (95% CI: 1.43—2.06; p = 0.0349; 15 studies), with a moderate degree of heterogeneity (I² = 42.99%).

Conclusion

This meta-analysis provides evidence of a significant association between asbestos exposure and ovarian cancer mortality. While the possibility of misdiagnosis in earlier studies cannot be completely ruled out, recent findings suggest a robust correlation between asbestos exposure and ovarian cancer. This highlights the importance of sustained efforts to minimize asbestos exposure and protect public health.

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石棉暴露与卵巢癌;一个荟萃分析

国际癌症研究机构(IARC)专著对石棉与卵巢癌之间的关系进行了系统的综述。然而，由于对少数文章给予了不适当的权重，可能存在信息偏差。为了解决这一局限性，本研究对2012年IARC石棉专著发布前后发表的研究进行了荟萃分析，目的是调查石棉暴露与卵巢癌之间的关系。方法对主要期刊数据库进行全面检索，以确定检查石棉暴露与卵巢癌之间关系的研究，包括2012年IARC石棉专著中的研究。对石棉暴露与癌症风险进行了荟萃分析。结果:对2012年IARC石棉专著发表后发表的研究进行荟萃分析发现，总标准化死亡率(SMR)为2.04 (95% CI, 1.03-4.05;P = 0.0123;5项研究)，研究之间存在显著的异质性(I2 = 72.99%)。对2012年IARC专著出版前后的15项研究的综合分析显示，总体总结SMR为1.72 (95% CI, 1.43-2.06;P = 0.0349;15项研究)，具有中等程度的异质性(I2 = 42.99%)。结论:本荟萃分析提供了石棉暴露与卵巢癌死亡率之间存在显著关联的证据。虽然不能完全排除早期研究中误诊的可能性，但最近的研究结果表明，石棉暴露与卵巢癌之间存在很强的相关性。这突出了持续努力尽量减少石棉接触和保护公众健康的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Safety and Health at Work Social Sciences-Safety Research

CiteScore

6.40

自引率

5.70%

发文量

1080

审稿时长

38 days

期刊介绍： Safety and Health at Work (SH@W) is an international, peer-reviewed, interdisciplinary journal published quarterly in English beginning in 2010. The journal is aimed at providing grounds for the exchange of ideas and data developed through research experience in the broad field of occupational health and safety. Articles may deal with scientific research to improve workers'' health and safety by eliminating occupational accidents and diseases, pursuing a better working life, and creating a safe and comfortable working environment. The journal focuses primarily on original articles across the whole scope of occupational health and safety, but also welcomes up-to-date review papers and short communications and commentaries on urgent issues and case studies on unique epidemiological survey, methods of accident investigation, and analysis. High priority will be given to articles on occupational epidemiology, medicine, hygiene, toxicology, nursing and health services, work safety, ergonomics, work organization, engineering of safety (mechanical, electrical, chemical, and construction), safety management and policy, and studies related to economic evaluation and its social policy and organizational aspects. Its abbreviated title is Saf Health Work.