Dual-Pathway Inhibition with Rivaroxaban and Low-Dose Aspirin Does Not Alter Immune Cell Responsiveness and Distribution in Patients with Coronary Artery Disease.
IF 3
Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
引用次数: 0
Abstract
Introduction: Cardiovascular diseases (CVD) are the leading cause of death globally. Inflammation is an important driver of CVD where tissue damage may lead to the formation of deadly thrombi. Therefore, antithrombotic drugs, such as platelet inhibitors, are crucial for secondary risk prevention in coronary artery disease (CAD) and peripheral artery disease (PAD). For severe forms of the disease, dual-pathway inhibition (DPI) where low-dose aspirin is combined with rivaroxaban has shown improved efficacy in reducing cardiovascular mortality.
Methods: Given this greater improvement in mortality, and the importance of inflammation in driving atherosclerosis, the potential for off-target inflammation-lowering effects of these drugs was evaluated by looking at the change in immune cell distribution and responsiveness to ex vivo lipopolysaccharide (LPS) stimulation after 3 months of DPI in patients with CAD.
Results: We observed no changes in whole blood or peripheral blood mononuclear cell (PBMC) immune cell responsiveness to LPS after 3 months of DPI. Additionally, we did not observe any changes in the distribution of total white blood cells, monocytes, neutrophils, lymphocytes, or platelets during the study course. Signs of systemic inflammation were studied using Olink proteomics in 33 patients with PAD after 3 months of DPI. No changes were observed in any of the inflammatory proteins measured after the treatment period, suggesting that the state of chronic inflammation was not altered in these subjects.
Conclusion: Three months of DPI does not result in any meaningful change in immune cell responsiveness and distribution in patients with CAD or PAD.
Trial registration: ClinicalTrials.gov ID: NCT05210725.
利伐沙班和小剂量阿司匹林的双途径抑制不会改变冠心病患者的免疫细胞反应性和分布。
引言心血管疾病（CVD）是导致全球死亡的主要原因。炎症是心血管疾病的重要诱因，组织损伤可能导致致命血栓的形成。因此，血小板抑制剂等抗血栓药物对于冠状动脉疾病（CAD）和外周动脉疾病（PAD）的二级风险预防至关重要。对于病情严重的患者，双通道抑制（DPI）疗法（即小剂量阿司匹林与利伐沙班联合应用）在降低心血管死亡率方面显示出更好的疗效：鉴于死亡率有了更大的改善，以及炎症在动脉粥样硬化中的重要作用，我们通过观察 CAD 患者服用 DPI 3 个月后免疫细胞分布的变化以及对体内外脂多糖（LPS）刺激的反应性，评估了这些药物可能产生的脱靶炎症降低效应：我们观察到，DPI 3 个月后，全血或外周血单核细胞（PBMC）免疫细胞对 LPS 的反应性没有变化。此外，在研究过程中，我们也没有观察到白细胞总数、单核细胞、中性粒细胞、淋巴细胞或血小板的分布有任何变化。在使用 DPI 3 个月后，我们使用 Olink 蛋白组学研究了 33 名 PAD 患者的全身炎症迹象。治疗期结束后，所测得的炎症蛋白均未发生变化，这表明这些受试者的慢性炎症状态并未改变：结论：三个月的 DPI 不会导致 CAD 或 PAD 患者的免疫细胞反应性和分布发生任何有意义的变化：试验注册：ClinicalTrials.gov ID：试验注册：ClinicalTrials.gov ID：NCT05210725。
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来源期刊
Cardiology and Therapy
CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.30
自引率
0.00%
发文量
38
审稿时长
6 weeks
期刊介绍：
Aims and Scope
Cardiology and Therapy is an international, open access, peer reviewed (single-blind), rapid-publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of cardiovascular therapies and interventions, including devices. Studies relating to diagnosis and diagnostics, pharmacoeconomics, public health, quality of life, as well as patient care, management and education are also encouraged.
Areas of focus include, but are not limited to, ischaemic heart disease and acute cardiac care, myocardial, valvular, pericardial and congenital heart disease, vascular and pulmonary disease (including hypertension), arrhythmias, heart failure, non-invasive diagnostic techniques, and invasive and interventional cardiology as well as cardiovascular surgery.
The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols and short communications such as commentaries and editorials. Cardiolology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals.
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The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of cardiovascular therapies.
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The journal’s dedicated in-house editorial team offer a personal “concierge service” meaning authors will always have an editorial contact able to update them on the status of their manuscript. The editorial team check all manuscripts to ensure that articles conform to the most recent COPE, GPP and ICMJE publishing guidelines. This supports the publication of ethically sound and transparent research.
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Upon acceptance of your article for publication, authors will be required to pay the mandatory Rapid Service Fee of £3650/€4500/$5100. The journal will consider fee discounts for developing countries and this is decided on a case by case basis.
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All articles published by Cardiology and Therapy are published open access.
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