Identification of a novel enzyme and the regulation of key enzymes in mammalian taurine synthesis

IF 3 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Teruo Miyazaki
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引用次数: 0

Abstract

Taurine has many pharmacological roles on various tissues. The maintenance of abundant taurine content in the mammalian body through endogenous synthesis, in addition to exogenous intake, is the essential factor for morphological and functional maintenances in most tissues. The synthesis of taurine from sulfur-containing amino acids is influenced by various factors. Previous literature findings indicate the influence of the intake of proteins and sulfur-containing amino acids on the activity of the rate-limiting enzymes cysteine dioxygenase and cysteine sulfinate decarboxylase. In addition, the regulation of the activity and expression of taurine-synthesis enzymes by hormones, bile acids, and inflammatory cytokines through nuclear receptors have been reported in liver and reproductive tissues. Furthermore, flavin-containing monooxygenase subtype 1 was recently identified as the taurine-synthesis enzyme that converts hypotaurine to taurine. This review introduces the novel taurine synthesis enzyme and the nuclear receptor-associated regulation of key enzymes in taurine synthesis.

哺乳动物牛磺酸合成中一种新酶的鉴定及关键酶的调控
牛磺酸在多种组织中具有多种药理作用。除了外源性摄入外,通过内源性合成维持哺乳动物体内丰富的牛磺酸含量,是大多数组织维持形态和功能的必要因素。含硫氨基酸合成牛磺酸受多种因素的影响。先前的文献发现表明蛋白质和含硫氨基酸的摄入对限速酶半胱氨酸双加氧酶和亚硫酸半胱氨酸脱羧酶活性的影响。此外,在肝脏和生殖组织中,激素、胆汁酸和炎症细胞因子通过核受体调节牛磺酸合成酶的活性和表达已被报道。此外,含有黄素的单加氧酶亚型1最近被确定为牛磺酸合成酶,将次牛磺酸转化为牛磺酸。本文综述了新型牛磺酸合成酶以及牛磺酸合成过程中关键酶的核受体相关调控。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.20
自引率
2.90%
发文量
104
审稿时长
31 days
期刊介绍: Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.
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