Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus.

IF 2.1 3区生物学 Q3 BIOCHEMICAL RESEARCH METHODS

Proteome Science Pub Date : 2023-12-01 DOI:10.1186/s12953-023-00215-8

Wei Wang, Wei Shi, Yinglan Wang, Yane Yang, Ping Li, Zhipeng Zeng, Wenlong Hu, Yumei Chen, Donge Tang, Yong Dai

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引用次数: 0

Abstract

Lung tissue is an important organ of the fetus, and genomic research on its development has improved our understanding of the biology of this tissue. However, the proteomic research of developing fetal lung tissue is still very scarce. We conducted comprehensive analysis of two developmental stages of fetal lung tissue of proteomics. It showed the developmental characteristics of lung tissue, such as the down-regulation of metabolism-related protein expression, the up-regulation of cell cycle-related proteins, and the regulation in proteins and pathways related to lung development. In addition, we also discovered some key core proteins related to lung development, and provided some key crotonylation modification sites that regulation during lung tissue development. Our comprehensive analysis of lung proteomics can provide a more comprehensive understanding of the developmental status of lung tissue, and provide a certain reference for future research and epigenetics of lung tissue.

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人胎儿假腺期和小管期肺赖氨酸巴豆酰化的系统蛋白质组学分析。

肺组织是胎儿的重要器官，对其发育的基因组研究提高了我们对该组织生物学的理解。然而，关于发育中的胎儿肺组织的蛋白质组学研究仍然非常匮乏。我们对两个发育阶段的胎儿肺组织进行了蛋白质组学的综合分析。它显示了肺组织的发育特征，如代谢相关蛋白的表达下调，细胞周期相关蛋白的表达上调，肺发育相关蛋白和通路的调节。此外，我们还发现了一些与肺发育相关的关键核心蛋白，并提供了一些在肺组织发育过程中调控的关键巴豆酰化修饰位点。我们对肺蛋白质组学的综合分析可以更全面地了解肺组织的发育状况，为今后肺组织的研究和表观遗传学提供一定的参考。

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来源期刊

Proteome Science 生物-生化研究方法

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

4.5 months

期刊介绍： Proteome Science is an open access journal publishing research in the area of systems studies. Proteome Science considers manuscripts based on all aspects of functional and structural proteomics, genomics, metabolomics, systems analysis and metabiome analysis. It encourages the submissions of studies that use large-scale or systems analysis of biomolecules in a cellular, organismal and/or environmental context. Studies that describe novel biological or clinical insights as well as methods-focused studies that describe novel methods for the large-scale study of any and all biomolecules in cells and tissues, such as mass spectrometry, protein and nucleic acid microarrays, genomics, next-generation sequencing and computational algorithms and methods are all within the scope of Proteome Science, as are electron topography, structural methods, proteogenomics, chemical proteomics, stem cell proteomics, organelle proteomics, plant and microbial proteomics. In spite of its name, Proteome Science considers all aspects of large-scale and systems studies because ultimately any mechanism that results in genomic and metabolomic changes will affect or be affected by the proteome. To reflect this intrinsic relationship of biological systems, Proteome Science will consider all such articles.