Molecular profiling in the management of hepatocellular carcinoma.

IF 1.8 4区 医学 Q3 TRANSPLANTATION
Nadine Soliman, Ashish Saharia, Maen Abdelrahim, Ashton A Connor
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引用次数: 0

Abstract

Purpose of review: The purpose of this review is to both summarize the current knowledge of hepatocellular carcinoma molecular biology and to suggest a framework in which to prospectively translate this knowledge into patient care. This is timely as recent guidelines recommend increased use of these technologies to advance personalized liver cancer care.

Recent findings: The main themes covered here address germline and somatic genetic alterations recently discovered in hepatocellular carcinoma, largely owing to next generation sequencing technologies, and nascent efforts to translate these into contemporary practice.

Summary: Early efforts of translating molecular profiling to hepatocellular carcinoma care demonstrate a growing number of potentially actionable alterations. Still lacking are a consensus on what biomarkers and technologies to adopt, at what scale and cost, and how to integrate them most effectively into care.

分子分析在肝细胞癌治疗中的应用。
综述的目的:本综述的目的是总结当前肝细胞癌分子生物学的知识,并提出一个框架,其中前瞻性地将这些知识转化为患者护理。这是及时的,因为最近的指南建议增加使用这些技术来推进个性化的肝癌治疗。最近的发现:本文所涵盖的主要主题是最近在肝细胞癌中发现的种系和体细胞遗传改变,这主要归功于下一代测序技术,以及将这些技术转化为当代实践的初步努力。摘要:早期将分子谱分析转化为肝细胞癌治疗的努力表明,越来越多的潜在可行的改变。对于采用何种生物标志物和技术,采用何种规模和成本,以及如何最有效地将它们整合到护理中,目前仍缺乏共识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.10
自引率
4.50%
发文量
124
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.
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