The Importance of Acromegaloid Physical Features for Clinical Practice.

IF 0.9 Q4 ENDOCRINOLOGY & METABOLISM
Case Reports in Endocrinology Pub Date : 2023-11-18 eCollection Date: 2023-01-01 DOI:10.1155/2023/5583344
Ivona Perić, Gordana Zamolo, Boris Bezak, Jasna Klen, Dubravka Jurišić-Eržen
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引用次数: 0

Abstract

Acromegaly and gigantism are hormonal disorders which develop as a consequence of chronic growth hormone hypersecretion. The prefix pseudo- is used to describe a certain clinical condition without a clearly proven characteristic of pathophysiological mechanism and basic biochemical features; pseudoacromegaly or acromegaloidism match the definition from above. In this case reports, we will try to provide a concise overview of diagnostic evaluation of acromegaloid physical appearance, while discussing two cases of patients who have similar clinical acromegaloid features as the first sign of the disease but have completely different etiologic backgrounds of their acromegalic appearance. The first case is of a 57-year-old male who presented with a marked acral growth and coarse facial features, but the diagnosis of secondary amyloidosis caused by multiple myeloma was confirmed just after biopsy of tongue and buccal mucosa. The second case is that of a 63-year-old male with an acromegaloid appearance caused by ectopic secretion of GH secreting lung carcinoma. The early diagnosis of ectopic acromegaly and pseudoacromegaly is still a challenging process. The key task is to confirm the GH axis abnormalities and establish the underlying disease, as a crucial step for faster treatment and need to avoid unnecessary therapeutic procedures to decreased mortality and improved quality of life.

肢端肥大体特征对临床的重要性。
肢端肥大症和巨人症是由于慢性生长激素分泌过多而导致的激素失调。前缀pseudo-用于描述没有明确证明的病理生理机制特征和基本生化特征的某种临床状况;假性肢端肥大症或肢端肥大症符合上述定义。在本病例报告中,我们将简要概述肢端肥大症物理外观的诊断评估,同时讨论两例患者,他们具有相似的临床肢端肥大症特征作为疾病的第一征兆,但其肢端肥大症外观的病因学背景完全不同。第一位病例是一位57岁男性,表现为肢端明显生长和面部特征粗糙,但在舌和颊粘膜活检后确诊为多发性骨髓瘤引起的继发性淀粉样变。第二例为63岁男性,因生长激素分泌型肺癌异位分泌而出现肢端巨细胞样外观。异位肢端肥大和假性肢端肥大的早期诊断仍然是一个具有挑战性的过程。关键任务是确认生长激素轴异常并确定潜在疾病,作为快速治疗的关键步骤,需要避免不必要的治疗程序,以降低死亡率和提高生活质量。
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来源期刊
Case Reports in Endocrinology
Case Reports in Endocrinology ENDOCRINOLOGY & METABOLISM-
CiteScore
2.10
自引率
0.00%
发文量
45
审稿时长
13 weeks
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