Adherence to Congestive Heart Failure Guidelines and Outcome in the Middle East.

IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Raed Aqel, Tareq Alzughayyar, Jihad Zalloum, Qais Salah, Qutaiba Qafisheh, Mahmoud Izraiq
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引用次数: 0

Abstract

Background: Adherence to Congestive Heart Failure with reduced Ejection Fraction (CHFrEF) guidelines is not easily attainable everywhere, particularly in countries with a high prevalence of low socioeconomic status, which includes many Middle Eastern countries. However, it is well-established that adherence to the guidelines is associated with lower mortality and morbidity rates.

Objective: Our objective is to investigate the adherence to the degree of treatment guideline in CHFrEF within a patient population in the Middle East and correlate the level of compliance both fully and partially with morbidity and mortality outcomes. Methods and Statistics: We conducted a retrospective study on patients with CHFrEF in the Middle East region who were maintained on Sacubitril/Valsartan for up to 4 years (190 patients). This study included follow-up assessments for morbidity and mortality rates and their correlation with the level of adherence to guidelines.

Results: Statistical analysis was performed using IBM SPSS® 27th version. In both the partial adherence group and the full adherence group, there was a statistically significant improvement in NYHA (pretreatment and post-treatment) and Ejection fraction (pretreatment and posttreatment). This means that regardless of the level of adherence to the use of Sacubitril/Valsartan in CHFrEF, there was an overall improvement in the morbidity and mortality rates over the four years of follow-up.

Conclusion: While we fully support the idea of achieving full CHFrEF guideline adherence, we recognize the difficulty of this task. Nevertheless, this study reinforces the notion that any degree of adherence to guideline is correlated with better morbidity and mortality rates over a long-term follow-up.

中东地区对充血性心力衰竭指南的依从性和结果。
背景:充血性心力衰竭伴射血分数降低(CHFrEF)指南并不是在所有地方都能得到遵守,特别是在社会经济地位低下的国家,这与许多中东国家相似。然而,遵守指南与较低的死亡率和发病率相关。目的:我们将调查中东患者人群中CHFrEF治疗指南的遵守程度,并将遵守程度与发病率和死亡率联系起来。方法和统计:一项对中东地区CHFrEF患者进行的回顾性研究,190例患者持续使用Sacubitril/缬沙坦长达4年,包括对发病率和死亡率的随访,以及它们与指南依从性水平的相关性。结果:采用IBM SPSS®27版进行统计分析。NYHA(治疗前和治疗后)在部分依从组和完全依从组均有统计学意义。此外,在部分依从组和完全依从组中,射血分数(治疗前和治疗后)具有统计学意义,因此,无论在CHFrEF中使用Sacubitril/缬沙坦的依从程度如何,在长达4年的随访中,发病率和死亡率都有改善。结论:尽管我们完全支持完全遵守CHFrEF指南,但我们认识到这项任务很难实现,尽管如此,本研究支持任何指南的遵守都与长期随访中更好的发病率和死亡率相关的主题。
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来源期刊
Current Cardiology Reviews
Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
10.50%
发文量
117
期刊介绍: Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.
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