Towards a better understanding of the long-lasting evolutionary history of Mycobacterium tuberculosis

IF 2.8 3区医学 Q3 IMMUNOLOGY

Tuberculosis Pub Date : 2023-11-25 DOI:10.1016/j.tube.2023.102374

Gaetan Senelle , Christophe Guyeux , Guislaine Refrégier , Christophe Sola

引用次数: 0

Abstract

The daily increasing sequencing of Mycobacterium tuberculosis has made it possible to establish an advanced phylogeny of this bacterium. It currently includes 9 lineages mainly affecting humans, completed by animal lineages, which form the Mycobacterium tuberculosis complex. Inherited from various historical approaches, this phylogeny is now based on Single Nucleotide Polymorphisms (SNPs), of which updates are frequently proposed. We present here evidence that the task needs refinements: some lineages have currently suboptimal defining SNPs, and many sublineages still need to be named and characterized. These findings are based on a new tool specifically designed to index the entire existing sequencing data. In this article, we focus on lineages 4.5, 4.7, 6 and 7. We take the opportunity to present some evidence that TB-annotator shows strong relevance, identifying well supported sublineages, as well as good global agreement with previous findings.

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为了更好地了解结核分枝杆菌的长期进化史

每日增加的测序结核分枝杆菌已经有可能建立这种细菌的高级系统发育。它目前包括9个主要影响人类的谱系，由动物谱系完成，形成结核分枝杆菌复合体。从各种历史方法中继承，这种系统发育现在基于单核苷酸多态性(snp)，其更新经常被提出。我们在这里提出的证据表明，这项任务需要改进:一些谱系目前具有次优的SNPs定义，许多子谱系仍然需要命名和表征。这些发现是基于一种专门设计的新工具，用于索引所有现有的测序数据。在本文中，我们主要关注谱系4.5、4.7、6和7。我们借此机会提出一些证据，表明TB-annotator显示出很强的相关性，识别出良好支持的子谱系，以及与先前发现的良好的全球一致性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tuberculosis 医学-呼吸系统

CiteScore

4.60

自引率

3.10%

发文量

审稿时长

49 days

期刊介绍： Tuberculosis is a speciality journal focusing on basic experimental research on tuberculosis, notably on bacteriological, immunological and pathogenesis aspects of the disease. The journal publishes original research and reviews on the host response and immunology of tuberculosis and the molecular biology, genetics and physiology of the organism, however discourages submissions with a meta-analytical focus (for example, articles based on searches of published articles in public electronic databases, especially where there is lack of evidence of the personal involvement of authors in the generation of such material). We do not publish Clinical Case-Studies. Areas on which submissions are welcomed include: -Clinical TrialsDiagnostics- Antimicrobial resistance- Immunology- Leprosy- Microbiology, including microbial physiology- Molecular epidemiology- Non-tuberculous Mycobacteria- Pathogenesis- Pathology- Vaccine development. This Journal does not accept case-reports. The resurgence of interest in tuberculosis has accelerated the pace of relevant research and Tuberculosis has grown with it, as the only journal dedicated to experimental biomedical research in tuberculosis.