Genetic linkage studies in bipolar disorder: a review.

Psychiatric developments Pub Date : 1989-01-01
C D Mellon
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Abstract

For the past 20 years, researchers have been using genetic linkage studies as a tool to better understand the etiology of bipolar disorder. During this time, there have been reports of linkage between the symptom complex of bipolar disorder and 7 genetic markers located on 4 different chromosomal areas. All of these reports continue to be surrounded by controversy causing some observers to consider the field to be ambiguous and contradictory. This review provides some historical perspective on the controversies, while outlining the current status and future direction of the field.

双相情感障碍的遗传连锁研究综述。
在过去的20年里,研究人员一直在使用遗传连锁研究作为更好地了解双相情感障碍病因的工具。在此期间,有报道称双相情感障碍的症状复合物与位于4个不同染色体区域的7个遗传标记之间存在联系。所有这些报告都继续被争议所包围,导致一些观察家认为这个领域是模糊和矛盾的。本文对这些争议提供了一些历史视角,同时概述了该领域的现状和未来方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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