Early bioavailability in day surgery: a comparison between orally, rectally, and intravenously administered paracetamol

Q4 Nursing

Ambulatory Surgery Pub Date : 2005-05-01 DOI:10.1016/j.ambsur.2005.02.001

P. Holmér Pettersson , A. Hein , A. Öwall , R.E. Anderson , J.G. Jakobsson

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引用次数: 7

Abstract

Purpose:

Compare early bioavailability of rectal, effervescent oral, and i.v. paracetamol.

Scope:

Five groups of N = 7 patients received 1 or 2 g paracetamol orally or rectally or 1 g i.v. immediately after day surgery. Paracetamol concentrations taken after 20, 40 and 80 min. Median plasma paracetamol concentrations for 1 versus 2 g effervescents were 78 (25–114) versus 108 (95–146) μmol L⁻¹ at 80 min and 16 (9–30) versus 17 (10–30) μmol L⁻¹ for 1 versus 2 g suppositories. Paracetamol i.v. gave median 97 (77–135) μmol L⁻¹ after 40 min.

Conclusion:

Only intravenously and 2 g effervescent paracetamol gave therapeutic concentrations during the period studied.

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日间手术的早期生物利用度:口服、直肠和静脉给药扑热息痛的比较

目的:比较直肠、泡腾式口服和静脉注射扑热息痛的早期生物利用度。研究范围:5组患者(N = 7)术后立即口服或直肠口服扑热息痛1 g或2 g，静脉注射扑热息痛1 g。20min、40min和80min后的扑热息痛浓度。80min时，1 g泡腾剂和2g栓剂的血浆中位扑热息痛浓度分别为78(25-114)和108 (95-146)μmol L−1,1g栓剂和2g栓剂的血浆中位扑热息痛浓度分别为16(9-30)和17 (10-30)μmol L−1。结论:在研究期间，只有静脉滴注和2 g泡腾性扑热息痛具有治疗浓度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ambulatory Surgery Medicine-Anesthesiology and Pain Medicine

CiteScore

0.30

自引率

0.00%

发文量