Empirical antibiotics for febrile neutropenic cancer patients.

J W Hathorn
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引用次数: 0

Abstract

The empirical institution of broad spectrum antibiotics for febrile neutropenic cancer patients has become standard medical practice. Traditionally, the antibiotics consisted of a combination of agents selected to maximize activity against the most commonly isolated pathogens, and often employed agents with synergistic antimicrobial activity. Recent additions to the antibiotic armamentarium, however, have provided single agents with equivalent spectra of activity, thus potentially allowing a 'monotherapeutic' alternative to the combination regimens. The empirical utilization of antibiotics for the febrile, neutropenic episode is reviewed, with emphasis on recent clinical studies evaluating select monotherapeutic 'agents'.

经验抗生素治疗发热性嗜中性粒细胞减少癌患者。
广谱抗生素治疗发热性嗜中性粒细胞减少癌患者的经验制度已成为标准的医疗实践。传统上,抗生素由选择的药物组合组成,以最大限度地提高对最常见的分离病原体的活性,并且通常采用具有协同抗菌活性的药物。然而,最近添加到抗生素药库中,提供了具有等效活性谱的单一药物,因此可能成为联合方案的“单一治疗”替代方案。回顾了抗生素对发热、中性粒细胞减少发作的经验利用,重点介绍了最近的临床研究,评估了选择的单一治疗“药物”。
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