[The position of the liver in the pathogenesis of atherosclerosis].

Abstract

The review deals with two complexes: 1. Role of hepatocytes in the origin and course of general atherosclerosis. 2. The "Perisinusoidal Functional Unit" as pathogenetic factor in atherosclerosis. The central place of hepatocytes in the metabolism of lipoproteins of both exogenous and endogenous origins points to the fact that hepatocytes have a key function in the pathogenesis of atherosclerosis. In order to play their role in the metabolism, lipoproteins have to be capable of reaching the hepatocytes and of getting back from them into the circulation. The requisite for that is the passage of lipoproteins through the sinusoidal wall, i.e. the endothelial sieve. Its structuring is thought to be the cause for both distinct manifestation of atherosclerosis in different species, especially due to exogenous supply of lipids, and increasing risk of atherosclerosis, e.g., by nicotine or certain drugs. The following question might be derived from latest international research: "Is atherosclerosis a liver disease with secondary consequences for the vascular system?"