Baseline and longitudinal cardiovascular health using Life's Essential 8 metrics with the risk of incident hypertension.

IF 1.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2023-12-31 Epub Date: 2023-11-20 DOI:10.1080/10641963.2023.2271190

Xue Tian, Jingxuan Feng, Shuohua Chen, Yijun Zhang, Xiaoli Zhang, Qin Xu, Penglian Wang, Shouling Wu, Anxin Wang

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引用次数: 0

Abstract

Objective: The quantification of cardiovascular health (CVH) was updated by the American Heart Association recently by using the "Life's Essential 8" (LE8) score. We aimed to investigate the associations of baseline and longitudinal CVH status measured by the new LE8 score (except for blood pressure) with the risk of hypertension.

Methods: A total of 52 990 participants with complete data on LE8 metrics and without hypertension were enrolled from the Kailuan study, Tangshan, China. The associations of incident hypertension with the overall baseline, time-updated, and time-varying CVH score (ranging 0 [lowest] to 100 [highest]), and each component of LE8, were assessed by Cox regressions.

Results: During a median follow-up of 10.73 years 28 380 cases of incident hypertension were identified. The risk of hypertension attenuated with increased CVH score (P_trend < 0.0001), the hazard ratios (HRs) in high CVH versus low CVH group was 0.54 (95% confidence interval [CI], 0.51-0.57) for baseline CVH, 0.47 (95% CI, 0.45-0.50) for time-updated CVH, and 0.59 (95% CI, 0.55-0.63) for time-varying CVH. The predictive value of CVH in predicting hypertension improved by using LE8 than using Life's Simple 7 metrics. Among LE8 components, body mass index score was the strongest risk factor for hypertension. Subgroup analyses showed that the benefit of a higher CVH score on hypertension was more prominent in young adults and in women (P_interaction < 0.05).

Conclusions: A higher CVH score assessed by new LE8 is associated with a lower risk of subsequent hypertension, especially young adults and women.

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基线和纵向心血管健康使用生命基本8指标与高血压事件的风险。

目的:美国心脏协会最近更新了心血管健康(CVH)的量化标准，采用“生命基本8”(LE8)评分。我们的目的是研究新的LE8评分测量的基线和纵向CVH状态(血压除外)与高血压风险的关系。方法:从中国唐山开滦研究中招募了52 990名LE8指标数据完整且无高血压的参与者。通过Cox回归评估高血压事件与总体基线、随时间更新和随时间变化的CVH评分(范围从0[最低]到100[最高])以及LE8各组成部分的关系。结果:在中位随访10.73年期间，发现28380例高血压病例。高血压的风险随着CVH评分的增加而减弱(p趋势< 0.0001)，高CVH组与低CVH组的风险比(hr)基线CVH为0.54(95%可信区间[CI]， 0.51-0.57)，时间更新CVH为0.47 (95% CI, 0.45-0.50)，时变CVH为0.59 (95% CI, 0.55-0.63)。与使用Life's Simple 7指标相比，使用LE8指标可提高CVH对高血压的预测价值。在LE8成分中，体重指数评分是高血压的最强危险因素。亚组分析显示，CVH评分较高对高血压的益处在年轻人和女性中更为突出(p < 0.05)。结论:新LE8评估的CVH评分越高，后续高血压的风险越低，尤其是年轻人和女性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.