G V Naccarelli, R L Rinkenberger, A H Dougherty, D M Fitzgerald
{"title":"Adverse effects of amiodarone. Pathogenesis, incidence and management.","authors":"G V Naccarelli, R L Rinkenberger, A H Dougherty, D M Fitzgerald","doi":"10.1007/BF03259911","DOIUrl":null,"url":null,"abstract":"<p><p>Amiodarone is an extremely effective antiarrhythmic agent for the treatment of both life-threatening ventricular arrhythmias and refractory supraventricular tachyarrhythmias. Subjective minor side effects are common with amiodarone but rarely require discontinuation of therapy and are often handled by dose reduction. Serious end-organ toxicity, including pulmonary fibrosis and drug-induced hepatitis, have been the most common indications for discontinuing amiodarone therapy in these patients.</p>","PeriodicalId":77748,"journal":{"name":"Medical toxicology and adverse drug experience","volume":"4 4","pages":"246-53"},"PeriodicalIF":0.0000,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03259911","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical toxicology and adverse drug experience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF03259911","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10
Abstract
Amiodarone is an extremely effective antiarrhythmic agent for the treatment of both life-threatening ventricular arrhythmias and refractory supraventricular tachyarrhythmias. Subjective minor side effects are common with amiodarone but rarely require discontinuation of therapy and are often handled by dose reduction. Serious end-organ toxicity, including pulmonary fibrosis and drug-induced hepatitis, have been the most common indications for discontinuing amiodarone therapy in these patients.
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