Identifying patients suitable for targeted adjuvant therapy: advances in the field of developing biomarkers for tumor recurrence following irradiation.

IF 1 Q4 PHARMACOLOGY & PHARMACY
S Jagasia, E Tasci, Ying Zhuge, K Camphausen, A V Krauze
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引用次数: 0

Abstract

Introduction: Radiation therapy (RT) is commonly used to treat cancer in conjunction with chemotherapy, immunotherapy, and targeted therapies. Despite the effectiveness of RT, tumor recurrence due to treatment resistance still lead to treatment failure. RT-specific biomarkers are currently lacking and remain challenging to investigate with existing data since, for many common malignancies, standard of care (SOC) paradigms involve the administration of RT in conjunction with other agents.

Areas covered: Established clinically relevant biomarkers are used in surveillance, as prognostic indicators, and sometimes for treatment planning; however, the inability to intercept early recurrence or predict upfront resistance to treatment remains a significant challenge that limits the selection of patients for adjuvant therapy. We discuss attempts at intercepting early failure. We examine biomarkers that have made it into the clinic where they are used for treatment monitoring and management alteration, and novel biomarkers that lead the field with targeted adjuvant therapy seeking to harness these.

Expert opinion: Given the growth of data correlating interventions with omic analysis toward identifying biomarkers of radiation resistance, more robust markers of recurrence that link to biology will increasingly be leveraged toward targeted adjuvant therapy to make a successful transition to the clinic in the coming years.

确定适合靶向辅助治疗的患者:放射治疗后肿瘤复发生物标志物的研究进展。
简介:放射治疗(RT)通常与化疗、免疫治疗和靶向治疗联合用于治疗癌症。尽管RT治疗有效,但由于耐药引起的肿瘤复发仍然导致治疗失败。目前缺乏RT特异性生物标志物,并且利用现有数据进行研究仍然具有挑战性,因为对于许多常见的恶性肿瘤,标准治疗(SOC)范例涉及RT与其他药物联合使用。涵盖领域:已建立的临床相关生物标志物用于监测,作为预后指标,有时用于治疗计划;然而,无法拦截早期复发或预测对治疗的前期抵抗仍然是限制患者选择辅助治疗的重大挑战。我们讨论拦截早期失败的尝试。我们研究了已经进入临床用于治疗监测和管理改变的生物标志物,以及引领该领域寻求利用这些靶向辅助治疗的新型生物标志物。专家意见:考虑到将干预与基因组学分析相关联的数据的增长,以确定放射耐药的生物标志物,与生物学相关的更强大的复发标志物将越来越多地用于靶向辅助治疗,以便在未来几年成功过渡到临床。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.30
自引率
0.00%
发文量
9
期刊介绍: Expert Review of Precision Medicine and Drug Development publishes primarily review articles covering the development and clinical application of medicine to be used in a personalized therapy setting; in addition, the journal also publishes original research and commentary-style articles. In an era where medicine is recognizing that a one-size-fits-all approach is not always appropriate, it has become necessary to identify patients responsive to treatments and treat patient populations using a tailored approach. Areas covered include: Development and application of drugs targeted to specific genotypes and populations, as well as advanced diagnostic technologies and significant biomarkers that aid in this. Clinical trials and case studies within personalized therapy and drug development. Screening, prediction and prevention of disease, prediction of adverse events, treatment monitoring, effects of metabolomics and microbiomics on treatment. Secondary population research, genome-wide association studies, disease–gene association studies, personal genome technologies. Ethical and cost–benefit issues, the impact to healthcare and business infrastructure, and regulatory issues.
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