6-Pyrazolylpurine and its deaza derivatives as nucleobases for silver(I)-mediated base pairing with pyrimidines

IF 2.7 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

JBIC Journal of Biological Inorganic Chemistry Pub Date : 2023-11-20 DOI:10.1007/s00775-023-02022-0

Daniela Escher, Tim Schäfer, Marian Hebenbrock, Jens Müller

引用次数: 0

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6-吡唑嘌呤及其二氮衍生物作为银(I)介导的嘧啶碱基配对的核碱基。

研究了人工核碱基6-吡唑嘌呤(6PP)及其二氮杂衍生物1-二氮杂-6-吡唑嘌呤(1D6PP)、7-二氮杂-6-吡唑嘌呤(7D6PP)和1,7-二氮杂-6-吡唑嘌呤(1,7d6pp)通过银(I)介导的碱基配对区分典型核碱基胞嘧啶和胸腺嘧啶的能力。通过温度依赖的紫外光谱和圆二色光谱显示，6PP和(在较小程度上)7D6PP与胞嘧啶形成稳定的银(I)介导的碱基对，但不与胸腺嘧啶形成。1D6PP和17d6pp不参与稳定银(I)介导的碱基对与胞嘧啶或胸腺嘧啶的形成。1D6PP、7D6PP和1,7d6pp的不同行为表明，银(I)的结合是通过嘌呤衍生物的N1位发生的，即通过沃森-克里克面。数据显示，6PP能够区分胞嘧啶和胸腺嘧啶，这可能与检测单核苷酸多态性有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JBIC Journal of Biological Inorganic Chemistry 化学-生化与分子生物学

CiteScore

5.90

自引率

3.30%

发文量

审稿时长

3 months

期刊介绍： Biological inorganic chemistry is a growing field of science that embraces the principles of biology and inorganic chemistry and impacts other fields ranging from medicine to the environment. JBIC (Journal of Biological Inorganic Chemistry) seeks to promote this field internationally. The Journal is primarily concerned with advances in understanding the role of metal ions within a biological matrix—be it a protein, DNA/RNA, or a cell, as well as appropriate model studies. Manuscripts describing high-quality original research on the above topics in English are invited for submission to this Journal. The Journal publishes original articles, minireviews, and commentaries on debated issues.