Computer assisted quantitative densitometric analysis of 125I-apamin binding sites in the central nervous system.

Acta physiologica Polonica Pub Date : 1989-03-01
P K Janicki, G Seibold, D Siembab, E A Paulo, Z Szreniawski
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引用次数: 0

Abstract

The binding sites for 125I-monoiododerivative of apamin in the central nervous system of rat, guinea-pig, chicken and frog were analysed and compared by computer assisted quantitative densitometric autoradiography on X-ray film. The highest level of binding sites in the rat and guinea-pig brain was found in the limbic-olfactory system and in the substantia gelatinosa of the spinal cord. In the chicken brain apamin binds preferentially to the tectum opticum and nuclei isthmi. In the frog brain no specific apamin binding sites were found. The role of presented topography for apamin binding sites is discussed in relation to neurotoxic properties of apamin.

中枢神经系统中125i -维生素结合位点的计算机辅助定量密度分析。
采用x射线胶片计算机辅助定量密度自显影技术,分析比较了大鼠、豚鼠、鸡和蛙的中枢神经系统中125i -单碘衍生物的结合位点。在大鼠和豚鼠的大脑中,在边缘嗅觉系统和脊髓明胶质中发现了最高水平的结合位点。在鸡脑中,维生素优先与视顶盖和峡核结合。在青蛙的大脑中没有发现特异性的维生素结合位点。所呈现的地形对维生素a结合位点的作用,讨论了与维生素a神经毒性的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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