Effect of ultraviolet B on nonimmunologic contact reactions induced by dimethyl sulphoxide, phenol and sodium lauryl sulphate.

Photo-dermatology Pub Date : 1989-12-01
E Larmi, A Lahti, M Hannuksela
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Abstract

The effect of ultraviolet light B (UVB) on immediate and delayed irritant reactions induced by dimethyl sulphoxide (DMSO), phenol, and sodium lauryl sulphate (SLS) was studied in 12 volunteers. One half of the upper back was irradiated with 0.16 J/cm2 of UVB. Patch tests for immediate reactions were performed using dilution series of test substances on the 3rd, 9th and 15th days and for delayed reactions on the 2nd, 8th and 14th days after irradiation both on the UV-exposed and non-exposed areas of the back. The occlusion time was 20 min for immediate reactions and 20 h for delayed ones. Changes in the skin blood flow of the test sites were monitored using laser-Doppler flowmetry, and erythema and edema reactions were observed visually. Both immediate and delayed reactions were caused by DMSO and phenol; SLS elicited only delayed reactions. UVB diminished immediate reactions induced by phenol for at least 15 days after irradiation. Immediate reactions to DMSO were diminished 40 min after application on the UV-exposed area on the 3rd day. UVB diminished the delayed reactions from SLS and DMSO but not reactions induced by phenol.

紫外线B对二甲基亚砜、苯酚和十二烷基硫酸钠诱导的非免疫接触反应的影响。
研究了紫外线B (UVB)对二甲基亚砜(DMSO)、苯酚和十二烷基硫酸钠(SLS)诱发的即时和延迟性刺激反应的影响。上背部的一半以0.16 J/cm2的UVB照射。在照射后第3天、第9天和第15天使用稀释系列测试物质进行即时反应的斑贴试验,在照射后第2天、第8天和第14天对背部紫外线暴露区和非暴露区进行延迟反应的斑贴试验。即刻反应阻断时间为20min,延迟反应阻断时间为20h。采用激光多普勒血流仪监测试验点皮肤血流变化,目测观察红斑和水肿反应。DMSO和苯酚均可引起立即反应和延迟反应;SLS只引起延迟反应。UVB在辐照后至少15天内减少了苯酚引起的直接反应。第3天,在暴露于紫外线的区域涂抹DMSO 40分钟后,对DMSO的立即反应减弱。UVB降低了SLS和DMSO的延迟反应,但对苯酚诱导的延迟反应没有影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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