Local increase in interleukin-1-like activity following UVB irradiation of human skin in vivo.

Photo-dermatology Pub Date : 1989-12-01
G M Murphy, P M Dowd, B N Hudspith, J Brostoff, M W Greaves
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Abstract

Using an in vivo skin chamber method, we demonstrated increased release of interleukin-1 (IL-1)-like activity at the site of irradiation with 3 times the minimal erythema dose of ultraviolet B (UVB). IL-1-like activity was estimated using the mouse thymocyte amplification assay. UVB-augmented release of IL-1-like activity peaked 1 h after irradiation and levels returned to baseline by 2 h. Release of IL-1-like activity from human skin after exposure to UV radiation may account for some of the local and systemic features of the sunburn response.

UVB照射人体皮肤后局部增加白细胞介素-1样活性。
使用体内皮肤腔法,我们证明了在3倍于最小红斑剂量的紫外线B (UVB)照射部位,白细胞介素-1 (IL-1)样活性的释放增加。利用小鼠胸腺细胞扩增试验估计il -1样活性。uvb增强的il -1样活性释放在照射后1小时达到峰值,并在2小时后恢复到基线水平。暴露于紫外线辐射后人体皮肤释放的il -1样活性可能解释了晒伤反应的一些局部和全身特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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