[The differential use of fibrinolysis activators and inhibitors in treating acute abscesses and gangrene of the lungs].

Grudnaia khirurgiia (Moscow, Russia) Pub Date : 1989-09-01
Ia N Shoĭkhet, L G Dukov, S V Zaremba, G I Kostiuchenko, L V Shuster
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Abstract

The authors examined 25 patients with acute abscesses and gangrene of the lungs to study the condition of the phagocyte system and its effect on processes of fibrin formation and destruction in the focus of inflammation. They found marked increase of the number of polymorphonuclear leucocytes and decrease of alveolar macrophages in lavage fluid of the diseased lung. The fibrinolytic, procoagulant, and oxygen-dependent metabolic activity of phagocytes was increased. With the degree of these changes and the clinical and endoscopic signs of the activity of the inflammatory process taken into account, the choice of the fibrinolysis activators and inhibitors for endobronchial administration can be differentiated and the results of treatment improved.

[纤维蛋白溶解激活剂和抑制剂在治疗急性肺脓肿和坏疽中的不同应用]。
作者检查了25例急性肺脓肿和坏疽,研究了吞噬系统的状况及其对炎症灶纤维蛋白形成和破坏过程的影响。他们发现病变肺灌洗液中多形核白细胞数量明显增加,肺泡巨噬细胞数量明显减少。吞噬细胞的纤溶、促凝和氧依赖代谢活性增加。考虑到这些变化的程度以及炎症过程活动性的临床和内镜征象,可以区分支气管内给药纤维蛋白溶解激活剂和抑制剂的选择,从而改善治疗结果。
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