Predictive value of antinuclear antibodies in autoimmune diseases classified by clinical criteria: Analytical study in a specialized health institute, one year follow-up

Results in immunology Pub Date : 2015-01-01 DOI:10.1016/j.rinim.2013.10.003

María Elena Soto , Nidia Hernández-Becerril , Ada Claudia Perez-Chiney , Alfredo Hernández-Rizo , José Eduardo Telich-Tarriba , Luis Eduardo Juárez-Orozco , Gabriela Melendez , Rafael Bojalil

{"title":"Predictive value of antinuclear antibodies in autoimmune diseases classified by clinical criteria: Analytical study in a specialized health institute, one year follow-up","authors":"María Elena Soto , Nidia Hernández-Becerril , Ada Claudia Perez-Chiney , Alfredo Hernández-Rizo , José Eduardo Telich-Tarriba , Luis Eduardo Juárez-Orozco , Gabriela Melendez , Rafael Bojalil","doi":"10.1016/j.rinim.2013.10.003","DOIUrl":null,"url":null,"abstract":"<div>Introduction: Determination of antinuclear antibodies (ANA) by indirect immunofluorescence (IIF) is usually the initial test for the diagnosis of systemic rheumatic diseases (SRD). Assigning predictive values to positive and negative results of the test is vital because lack of knowledge about ANAs and their usefulness in classification criteria of SRD leads to inappropriate use. Methods: Retrospective study, ANA tests requested by different specialties, correlation to patients' final diagnosis. Results: The prevalence of autoimmune disease was relatively low in our population yielding a low PPV and a high NPV for the ANA test. 40% of the patients had no clinical criteria applied prior to test. Coexistence of two or more autoimmune disorders affects prevalence and predictive values. Conclusion: Application of the test after careful evaluation for clinical criteria remarkably improves the positive likelihood ratio for the diagnosis.</div>","PeriodicalId":89845,"journal":{"name":"Results in immunology","volume":"5 ","pages":"Pages 13-22"},"PeriodicalIF":0.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rinim.2013.10.003","citationCount":"36","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Results in immunology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211283913000178","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 36

Abstract

Introduction: Determination of antinuclear antibodies (ANA) by indirect immunofluorescence (IIF) is usually the initial test for the diagnosis of systemic rheumatic diseases (SRD). Assigning predictive values to positive and negative results of the test is vital because lack of knowledge about ANAs and their usefulness in classification criteria of SRD leads to inappropriate use. Methods: Retrospective study, ANA tests requested by different specialties, correlation to patients' final diagnosis. Results: The prevalence of autoimmune disease was relatively low in our population yielding a low PPV and a high NPV for the ANA test. 40% of the patients had no clinical criteria applied prior to test. Coexistence of two or more autoimmune disorders affects prevalence and predictive values. Conclusion: Application of the test after careful evaluation for clinical criteria remarkably improves the positive likelihood ratio for the diagnosis.

查看原文本刊更多论文

抗核抗体对自身免疫性疾病临床分类的预测价值:某专业卫生机构一年随访的分析研究

简介:间接免疫荧光法(IIF)检测抗核抗体(ANA)通常是诊断全身性风湿病(SRD)的初始检测方法。为阳性和阴性结果分配预测值至关重要，因为缺乏对ANAs及其在SRD分类标准中的有用性的了解导致使用不当。方法:回顾性研究，不同专科要求的ANA检查与患者最终诊断的相关性。结果:自身免疫性疾病的患病率在我们的人群中相对较低，因此ANA测试的PPV较低，NPV较高。40%的患者在检测前没有应用临床标准。两种或两种以上自身免疫性疾病的共存影响患病率和预测值。结论:在仔细评估临床标准后应用该试验可显著提高诊断的阳性似然比。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Results in immunology

自引率

0.00%

发文量