The influence of exaprolol upon the ischaemic rat heart and its interaction with sarcolemmal (Na+ + K+)-ATPase.

Physiologia Bohemoslovaca Pub Date : 1989-01-01

A Dzurba, E Barta, J Styk, J Okolicány, A Ziegelhöffer

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Abstract

The capability of cyclohexylphenol exaprolol of protecting the ischaemic myocardium during ischaemic cardiac arrest was assessed in the isolated working rat heart. Exaprolol added to the perfusion medium in a dose of 10(-7) mol.l-1 only minimally influenced the left ventricular function (reduced the stroke volume by 18.84% and cardiac output by 14.63%). The hearts were subjected to global ischaemia for 75 min at 26 degrees C and subsequently reperfused for 60 min at 37 degrees C. The recovery of left ventricular function following reperfusion, expressed as a percentage of preischaemic functional performance was used as an indicator of the ischaemic tolerance of the heart. The effect of exaprolol on sarcolemmal (Na+ + K+)-, Mg2+- and Ca2+-ATPase activities was also examined. Exaprolol-pretreated hearts revealed better postischaemic recovery of the left ventricular dP/dt max and stroke volume as well as improved efficiency in the transformation of chemical energy to mechanical work. Exaprolol in 10(-4) mol.l-1 concentration significantly stimulated the specific activity of sarcolemmal (Na+ + K+)-ATPase. Possible mechanisms of the salutary effect of exaprolol on the ischaemic heart are discussed.

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艾美洛尔对缺血大鼠心脏的影响及其与肌上皮(Na+ + K+)- atp酶的相互作用。

在离体工作大鼠心脏上评价环己基酚阿替洛尔对缺血性心脏骤停时缺血心肌的保护作用。在灌注介质中加入10(-7)mol.l-1剂量的艾伐洛尔仅对左心室功能有轻微影响(使脑卒中容积减少18.84%，心输出量减少14.63%)。心脏在26℃下缺血75分钟，随后在37℃下再灌注60分钟。再灌注后左心室功能的恢复，以缺血前功能表现的百分比表示，作为心脏缺血耐受性的指标。研究了艾美洛尔对肌上皮(Na+ + K+)-、Mg2+-和Ca2+- atp酶活性的影响。经艾萨普洛尔预处理的心脏缺血后左心室dP/dt max和脑卒中容量恢复较好，化学能转化为机械能的效率也有所提高。10(-4) mol.l-1浓度的艾伐洛尔显著刺激了肌层(Na+ + K+)- atp酶的比活性。讨论了艾美洛尔对缺血性心脏有益作用的可能机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Physiologia Bohemoslovaca

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