Effects of forskolin on the longitudinal internal resistance (ri) in rabbit sinus node strips.

Acta physiologica Polonica Pub Date : 1989-03-01
W Tuganowski, I Korczyńska, K Wasik, B Wójcik, M Bukowski
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Abstract

The effect of several concentrations of 7-0-hemisuccinyl, 7-deacetyl forskolin on ri was studied by means of microelectrode and single sucrose gap techniques. Twenty mumol.l-1 of forskolin added to the sucrose gap lowered ri by 15% below the control value. The drug applied at 50 mumol.l-1 initially decreased ri by 31%, and then it increased the resistance by 43% above the control value. The possible mechanisms underlying these effects are discussed in terms of cAMP and Ca action on the cell coupling.

福斯可林对兔窦结条纵向内阻的影响。
采用微电极和单蔗糖间隙技术研究了不同浓度的7-0-半琥珀酰、7-去乙酰福斯olin对ri的影响。二十mumol。在蔗糖间隙中添加L-1的福斯克林,可使稻谷生长速率比控制值低15%。药物剂量为50 μ mol。L-1先使ri降低31%,然后使抗性比对照值提高43%。从cAMP和Ca对细胞偶联作用的角度讨论了这些效应的可能机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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