Delta-sleep inducing peptide (DSIP) and its fragments as the modulators of neural transmission in the central nervous system.

Acta physiologica Polonica Pub Date : 1989-07-01
S Kosiński, M Wieczerzak, A Janecka, W Koziołkiewicz
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引用次数: 0

Abstract

The present study is a continuation of our previous experiments on DSIP activity which have revealed that nonapeptide DSIP inhibits hippocampal electrical activity of the 4-7 c/s frequency band. The aim of the present study was to find which of the known DSIP fragments is responsible for its activity, i.e. to find the active site of the molecule. The experiments were carried out with the entire DSIP molecule and its three different fragments. The method of threshold continuous arousal pattern (TCAP) monitoring was used as the indicator of DSIP activity. It was found that the entire DSIP molecule increased TCAP, while its 1-5 fragment decreased it 1-4 and 5-9 fragments had no noticeable effect.

睡眠诱导肽(DSIP)及其片段在中枢神经系统中的神经传递调节作用。
本研究是我们之前关于DSIP活性的实验的延续,这些实验揭示了非肽DSIP抑制海马4-7 c/s频段的电活动。本研究的目的是找出哪个已知的DSIP片段负责其活性,即找到分子的活性位点。实验是用整个DSIP分子及其三个不同的片段进行的。采用阈值连续唤醒模式(TCAP)监测方法作为DSIP活动的指标。结果发现,DSIP分子的1-5片段使TCAP升高,而其1-4片段使TCAP降低,而5-9片段对TCAP无明显影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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