Photodynamic therapy--coming of age.

Photo-dermatology Pub Date : 1989-10-01
B W Henderson
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Abstract

With the advent of Phase III clinical trials, photodynamic therapy of solid tumors is about to gain respectability within the field of cancer therapy. This treatment modality uses visible light to activate tumor-localizing photosensitizers, and causes tissue destruction by generating highly cytotoxic molecular oxygen species. The almost universal tumor response achievable, mild general toxicity, and repeatability of treatment without loss of effectiveness account for its application in a wide variety of human neoplasms. A decade of basic and preclinical research has laid a solid foundation of knowledge of the mechanisms of the photodynamic effect, both on the cellular and tissue levels. Although open questions remain, these efforts have provided the rationale for new directions of development, such as the design of new photosensitizers and improved light sources. This report describes the events involved in photodynamic tumor destruction, emphasizing possible ways to improve this therapy in the future.

光动力疗法——成熟。
随着三期临床试验的到来,光动力治疗实体肿瘤即将在癌症治疗领域获得一席之地。这种治疗方式使用可见光来激活肿瘤定位光敏剂,并通过产生高细胞毒性的分子氧来破坏组织。几乎所有的肿瘤反应都可以实现,一般毒性轻微,治疗的可重复性而不丧失有效性,这说明了它在各种人类肿瘤中的广泛应用。十年来的基础研究和临床前研究为细胞和组织水平的光动力效应机制奠定了坚实的知识基础。尽管还存在一些悬而未决的问题,但这些努力为新的发展方向提供了基本原理,例如设计新的光敏剂和改进的光源。本报告描述了光动力肿瘤破坏所涉及的事件,强调了未来改进这种治疗的可能方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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