Experimentally induced acute changes in veins studied by scanning microscopy.

Abstract

Endothelial damage caused by hypoxia and the local administration of Varicocid, or by using vascular clamps on the jugular vein of rabbits, was studied under a scanning electron microscope. Adhering platelets and fibrin were found only in the acutely damaged veins with endothelial defects. Swelling and vacuolization of endothelial cells did not induce intravascular coagulation. Adhering thrombocyte aggregates and fibrin strands can be found on the venous wall after acute changes under a scanning microscope only if part or all of the endothelial lining has been lost. Intravascular coagulation is not induced by swelling or vacuolization. The jugular vein of rabbits was studied after hypoxia, the administration of Varicocid and the use of vascular clamps.