L. Zecchinon, T. Fett, P. Vanden Bergh, D. Desmecht
{"title":"Key roles of LFA-1 in leukocyte migration and immune response","authors":"L. Zecchinon, T. Fett, P. Vanden Bergh, D. Desmecht","doi":"10.1016/j.cair.2006.09.003","DOIUrl":null,"url":null,"abstract":"<div><p><span>To patrol the body effectively for infectious organisms, the cells of the immune system must both circulate as nonadherent cells in the blood and lymph and, in the presence of a foreign antigen, be able to congregate in lymphoid organs, cross endothelial and basement membranes to aggregate at sites of infection, and adhere to cells bearing foreign antigen. In this context, lymphocyte function-associated antigen-1 (LFA-1, α</span><sub>L</sub>β<sub>2</sub>, CD11a/CD18) plays a critical role (1) in forming stable bonds with counter receptors in the vascular walls to allow leukocytes to leave the circulation and (2) in validating the interaction between an antigen presenting cell and a T lymphocyte. Both roles are described in detail in this review.</p></div>","PeriodicalId":89340,"journal":{"name":"Clinical and applied immunology reviews","volume":"6 3","pages":"Pages 191-200"},"PeriodicalIF":0.0000,"publicationDate":"2006-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cair.2006.09.003","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and applied immunology reviews","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1529104906000511","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
To patrol the body effectively for infectious organisms, the cells of the immune system must both circulate as nonadherent cells in the blood and lymph and, in the presence of a foreign antigen, be able to congregate in lymphoid organs, cross endothelial and basement membranes to aggregate at sites of infection, and adhere to cells bearing foreign antigen. In this context, lymphocyte function-associated antigen-1 (LFA-1, αLβ2, CD11a/CD18) plays a critical role (1) in forming stable bonds with counter receptors in the vascular walls to allow leukocytes to leave the circulation and (2) in validating the interaction between an antigen presenting cell and a T lymphocyte. Both roles are described in detail in this review.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
