Researches on the influence of some pharmacological interferences of the metabolism of icosanoids on the glycemia in rats.

Abstract

We studied the influence of cloprostenol (CIPG) 200 micrograms/Kg i.p. (a synthetic analogue of PGF2-alpha) and of imidazol 70 mg/Kg i.p. (a selective inhibitor of thromboxane synthetase) on fasting glycemia and on hypoglycemia induced by Actrapid insulin 0.5 UI/Kg i.p. to rats (male adults). The determinations of glycemia were made 60 minutes and 3 hours after the administration of the substances. The tests were made in groups of 20 animals which were not fed 14 hours before the experiment, but were not deprived of water. The results were interpreted statistically by means of the "t" test. The data obtained show that CIPG 200 micrograms/Kg i.p. is a significant hyperglycemic icosanoid (statistically p less than 0.01) both in the case of fasting glycemia and in the case of insulin hypoglycemia. The hyperglycemic effect was stronger at 60 min. Imidazol does not modify significantly either glycemia or insulin hypoglycemia, which pleads for a more reduced implication of thromboxanes in the regulation of glycemia in comparison to the prostaglandins.