[Islet transplantation in type II diabetes mellitus--model of the spontaneous diabetic Cohen rat].

S Wiegand, R G Bretzel, A M Cohen, K Federlin
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Abstract

The spontaneous diabetic Cohen-rat is one of the few animal models of the diabetes mellitus Type II (NIDDM). A spontaneous diabetic animal line and a diabetes-resistant line originated from a parental lineage by genetic selection with regard to the glucose tolerance on condition of feeding of a saccharose-rich and copper-poor diet. In each case 1000 islets of the diabetes-resistant line were transplanted in 28 animals of the diabetic line. Body weight, blood-sugar concentration, glucosuria, glucose tolerance, and the HbA1 were normalized after the transplantation. The serum levels of insulin and glucagon increased. These results emphasize etiopathogenetic importance of the islets of Langerhans in this animal model.

胰岛移植治疗II型糖尿病——自发性糖尿病Cohen大鼠模型。
自发性糖尿病cohen大鼠是为数不多的2型糖尿病(NIDDM)动物模型之一。自发糖尿病动物系和抗糖尿病动物系在高糖低铜饮食条件下通过基因选择产生于亲代谱系。在每个病例中,将1000个糖尿病抵抗系的胰岛移植到28只糖尿病系的动物身上。移植后体重、血糖、血糖、糖耐量、HbA1均恢复正常。血清胰岛素和胰高血糖素水平升高。这些结果强调了这种动物模型中朗格汉斯胰岛的发病重要性。
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