Utilizing databases for astrocyte secretome research.

IF 3.8 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Expert Review of Proteomics Pub Date : 2023-07-01 Epub Date: 2023-12-30 DOI:10.1080/14789450.2023.2285311

Ruqayya Afridi, Won-Ha Lee, Jong-Heon Kim, Kyoungho Suk

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引用次数: 0

Abstract

Introduction: Astrocytes are the most abundant cell type in the central nervous system (CNS). They play a pivotal role in supporting neuronal function and maintaining homeostasis by releasing a variety of bioactive proteins, collectively known as the astrocyte secretome. Investigating secretome provides insights into the molecular mechanisms underlying astrocyte function and dysfunction, as well as novel strategies to prevent and treat diseases affecting the CNS.

Areas covered: Proteomics databases are a valuable resource for studying the role of astrocytes in healthy and diseased brain function, as they provide information about gene expression, protein expression, and cellular function. In this review, we discuss existing databases that are useful for astrocyte secretome research.

Expert opinion: Astrocyte secretomics is a field that is rapidly progressing, yet the availability of dedicated databases is currently limited. To meet the increasing demand for comprehensive omics data in glia research, developing databases specifically focused on astrocyte secretome is crucial. Such databases would allow researchers to investigate the intricate molecular landscape of astrocytes and comprehend their involvement in diverse physiological and pathological processes. Expanding resources through the development of databases dedicated to the astrocyte secretome may facilitate further advancements in this field.

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利用数据库进行星形胶质细胞分泌组研究。

星形胶质细胞是中枢神经系统(CNS)中最丰富的细胞类型。它们通过释放各种生物活性蛋白(统称为星形胶质细胞分泌组)，在支持神经元功能和维持体内平衡方面发挥关键作用。研究分泌组可以深入了解星形胶质细胞功能和功能障碍的分子机制，以及预防和治疗影响中枢神经系统的疾病的新策略。涵盖领域:蛋白质组学数据库是研究星形胶质细胞在健康和患病脑功能中的作用的宝贵资源，因为它们提供了有关基因表达、蛋白质表达和细胞功能的信息。本文综述了星形胶质细胞分泌组研究中常用的数据库。专家意见:星形胶质细胞分泌组学是一个快速发展的领域，但目前专用数据库的可用性有限。为了满足胶质细胞研究中对综合组学数据日益增长的需求，开发专门针对星形胶质细胞分泌组的数据库至关重要。这样的数据库将使研究人员能够研究星形胶质细胞复杂的分子景观，并了解它们参与各种生理和病理过程。通过开发专门用于星形胶质细胞分泌组的数据库来扩大资源，可能会促进这一领域的进一步发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Proteomics 生物-生化研究方法

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Review of Proteomics (ISSN 1478-9450) seeks to collect together technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease. The journal coverage includes, but is not limited to, overviews of specific technological advances in the development of protein arrays, interaction maps, data archives and biological assays, performance of new technologies and prospects for future drug discovery. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion - a personal view on the most effective or promising strategies and a clear perspective of future prospects within a realistic timescale Article highlights - an executive summary cutting to the author''s most critical points.