Estimation of Median Lethal Concentration (LC50) of Pyrethroid and Carbamates Pesticides using the Nematode Caenorhabditis elegans to Predict Mammalian Acute Lethality (LD50)

Q4 Pharmacology, Toxicology and Pharmaceutics

Toxicology International Pub Date : 2023-09-20 DOI:10.18311/ti/2023/v30i3/31834

Krishna Rana, Priyanka Gautam

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引用次数: 0

Abstract

Present study was aimed to estimate the median lethal concentration of most extensively used pesticides, pyrethroid (transfluthrin and cyfluthrin) and carbamates’ pesticides (methiocarb and propoxur to deter pests, using a free-living nematode, Caenorhabditis elegans as model organism. The median Lethal Concentration (LC50) was calculated by Log-dose/ probit regression line method, and Worms showed 24-hours lethality at concentrations 37 mg/l, 61 mg/l, 63 mg/l, and 48 mg/l for transfluthrin, cyfluthrin and methiocarb, propoxur respectively on NGM. Structural and toxicidal differences may has been for Differences in the median lethal concentration. LD50 and LC50 values data was compare with mammalian oral LD50 and calculated LC50 using C. elegans respectively. C. elegans found to be the more convenient for generating LC50 values analogous to the mammals LD50 values. So, C. elegans has great promises in the area of toxicological research.

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拟除虫菊酯类和氨基甲酸酯类杀虫剂利用线虫的致死浓度(LC50)预测哺乳动物急性死亡率(LD50)

本研究旨在以一种自由生活的线虫秀丽隐杆线虫为模式生物，估计最广泛使用的杀虫剂、拟除虫菊酯(跨氟菊酯和氟氯菊酯)和氨基甲酸酯类杀虫剂(甲硫威和残杀威)的致死浓度中值。采用对数剂量/概率回复线法计算中位致死浓度(LC50)，经氟氯氰菊酯、氟氯氰菊酯和残杀威分别在37、61、63、48 mg/l浓度下对NGM有24小时的致死效果。结构和毒性的差异可能是由于中位致死浓度的差异。将LD50和LC50值数据分别与哺乳动物口服LD50和线虫计算LC50值进行比较。秀丽隐杆线虫更容易产生与哺乳动物相似的LC50值。因此，秀丽隐杆线虫在毒理学研究领域具有广阔的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicology International Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Toxicology International is a peer-reviewed International Research Journal published bi-annually by the Society of Toxicology, India. The Journal is concerned with various disciplines of Toxicology including man, animals, plants and environment and publishes research, review and general articles besides opinions, comments, news-highlights and letters to editor.

Estimation of Median Lethal Concentration (LC<Sub>50</Sub>) of Pyrethroid and Carbamates Pesticides using the Nematode <i>Caenorhabditis elegans</i> to Predict Mammalian Acute Lethality (LD<Sub>50</Sub>)

Abstract