Solvent-Free Green Synthesis of New Isoquinazoline Derivatives Using Three Component Reactions of Isothiocyanates

IF 2.4 3区化学 Q2 CHEMISTRY, ORGANIC

Polycyclic Aromatic Compounds Pub Date : 2024-10-20 DOI:10.1080/10406638.2023.2271114

引用次数: 0

Abstract

In this work new isoquinazoline derivatives were synthesized in excellent yields using three component reactions of isoquinoline or its derivatives, isothiocyanates, and 1-(6-amino-2-(prop-1-en-2-yl)benzofuran-5-yl)ethan-1-one in the presence of triethylamine (Et₃N) under solvent-free conditions at room temperature. Also, the antioxidant activity of some synthesized isoquinazoline was studied using trapping of radical by DPPH and ferric reduction activity potential (FRAP) experiment. The short time of reaction, high yields of products, easy separation of products are some benefits of this procedure.

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利用异硫氰酸酯的三组分反应无溶剂绿色合成新的异喹唑啉衍生物

本研究在室温无溶剂条件下，利用异喹啉或其衍生物、异硫氰酸盐和 1-(6-氨基-2-(丙-1-烯-2-基)苯并呋喃-5-基)乙-1-酮的三组分反应合成了新的异喹唑啉衍生物，产量极高。此外，还利用 DPPH 自由基捕获和铁还原电位（FRAP）实验研究了一些合成异喹唑啉的抗氧化活性。该方法具有反应时间短、产物收率高、易于分离等优点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polycyclic Aromatic Compounds 化学-有机化学

CiteScore

3.70

自引率

20.80%

发文量

412

审稿时长

3 months

期刊介绍： The purpose of Polycyclic Aromatic Compounds is to provide an international and interdisciplinary forum for all aspects of research related to polycyclic aromatic compounds (PAC). Topics range from fundamental research in chemistry (including synthetic and theoretical chemistry) and physics (including astrophysics), as well as thermodynamics, spectroscopy, analytical methods, and biology to applied studies in environmental science, biochemistry, toxicology, and industry. Polycyclic Aromatic Compounds has an outstanding Editorial Board and offers a rapid and efficient peer review process, as well as a flexible open access policy.