Monoclonal War: The Antibody Arsenal and Targets for Expanded Application

Immuno Pub Date : 2023-09-20 DOI:10.3390/immuno3030021
Eric H. Rosenn, Mickael Benhaim, Allison Siegel, David A. Stein, Joseph S. Leonard, Erik Katcher, Dania Halperin, Zachary Mostel
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Abstract

Advancements in sequencing and screening technology have made monoclonal antibodies more accessible, cost-effective, and precise. These drugs effectively target pathogens and cancer cells and even regulate metabolic pathways by focusing on specific intermediates. Monoclonal antibodies play a key role in mitigating a rise in occupation-related cancers, neurodegenerative disorders, and multidrug-resistant organisms. Here, we review the origins, mechanisms, and applications of this important drug class and explore future avenues for research.
单克隆战争:抗体库和扩大应用的靶点
测序和筛选技术的进步使单克隆抗体更容易获得,成本效益更高,更精确。这些药物有效地靶向病原体和癌细胞,甚至通过专注于特定的中间体来调节代谢途径。单克隆抗体在减轻职业相关癌症、神经退行性疾病和多药耐药生物的上升中发挥关键作用。在这里,我们回顾了这一重要药物类别的起源、机制和应用,并探讨了未来的研究途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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