The Prospect of Focal Ultrasound in the Treatment of Mental Disorders

IF 1.2 Q4 PSYCHIATRY
Carlos Trenado, Nicole Pedroarena-Leal, Diane Ruge
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引用次数: 0

Abstract

Mental disorders critically affect an individual’s quality of life by disrupting cognitive abilities and emotional states and are a major health burden worldwide. At present, psychotherapy and pharmacological interventions are the main approaches to target the symptoms associated with such disorders; however, some patients become treatment-resistant and thus, alternative treatments are needed. Focal ultrasound (FUS) is an emerging non-invasive therapeutic technology that relies on the use of sound waves to target brain regions with high specificity and without the need for incision or radiation. As a result, FUS has been proposed as a potential treatment for mental diseases as it may help to overcome several issues of current neuromodulation approaches. Here, we discuss basic neuroscience and clinical studies on the application of FUS and highlight perspectives and challenges of the technology as well as opportunities, for instance, regarding stimulation of deep brain structures with potential implication in modulating brain neuroplasticity of relevant cortical and subcortical pathways.
局灶超声在精神障碍治疗中的应用前景
精神障碍通过破坏认知能力和情绪状态严重影响个人的生活质量,是世界范围内的一个主要健康负担。目前,心理治疗和药物干预是针对此类疾病相关症状的主要方法;然而,一些患者变得耐药,因此,需要替代治疗。局灶超声(FUS)是一种新兴的非侵入性治疗技术,它依赖于使用声波来靶向大脑区域,具有高特异性,无需切口或放射。因此,FUS被认为是一种潜在的精神疾病治疗方法,因为它可能有助于克服当前神经调节方法的几个问题。在这里,我们讨论了FUS应用的基础神经科学和临床研究,并强调了该技术的前景和挑战以及机遇,例如,刺激脑深部结构可能影响相关皮层和皮层下通路的大脑神经可塑性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.90
自引率
0.00%
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0
审稿时长
11 weeks
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