Medicinal plants with antileishmanial activity on parasites responsible for new-world cutaneous leishmaniasis. A systematic review 2018-2022

IF 1.2 Q4 PHARMACOLOGY & PHARMACY
Yenny Y. Lozano, Sara E. Giraldo, Angela C. Zapata, Jesús E. Escobar, Ruth M. Sánchez
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引用次数: 0

Abstract

Context: Cutaneous leishmaniasis is a disease of public health importance; treatment is based on the use of pentavalent antimonials with high toxicity and low efficacy; therefore, it´s necessary to search for therapeutic alternatives derived from natural products, based on the study of medicinal plants as a source of molecules with highly effective leishmanicidal potential. Aims: To carry out a systematic review between 2018 and 2022 on medicinal plants with potential leishmanicidal activity on parasite strains from the New World causing cutaneous leishmaniasis. Methods: The review study was conducted in four phases following the PRISMA methodology. First, research questions and objectives were formulated to establish the topic areas and construct the search algorithm. Second, a search was performed across different databases, including ScienceDirect, Scopus, PubMed, Web of Science, EBSCO, Taylor and Francis, and Scielo. Third, articles were chosen based on specific inclusion and exclusion criteria. Finally, the relevant information for the review was systematically organized. Results: The search yielded 163 articles, and 12 of them were selected as the basis for the construction of the review. Ethanolic and aqueous extracts stand out, as well as biocompounds such as terpenes and flavonoids. Antioxidant activity on reactive oxygen species was the most frequently cited. Conclusions: Promising terpene and flavonoid molecules with high antileishmanial activity (IC50 <2 μM or <10 μg/mL and SI >1) were identified in this study; these findings provide a scientific basis for the traditional use that communities have given to plants as a therapeutic source to treat cutaneous leishmaniasis in the New World.
对引起新世界皮肤利什曼病的寄生虫具有抗利什曼活性的药用植物。2018-2022年系统回顾
背景:皮肤利什曼病是一种具有公共卫生重要性的疾病;治疗的基础是使用高毒性、低疗效的五价锑;因此,有必要在研究药用植物作为具有高效利什曼尼分子来源的基础上,从天然产物中寻找治疗替代品。目的:对2018年至2022年间对引起皮肤利什曼病的新世界寄生虫株具有潜在杀利什曼活性的药用植物进行系统评价。方法:按照PRISMA方法学分为四个阶段进行回顾性研究。首先,制定研究问题和目标,建立主题领域,构建搜索算法。其次,在不同的数据库中进行搜索,包括ScienceDirect、Scopus、PubMed、Web of Science、EBSCO、Taylor and Francis和Scielo。第三,根据具体的纳入和排除标准选择文章。最后,对评审的相关资料进行了系统整理。结果:检索到163篇文献,选取其中12篇作为构建综述的依据。乙醇和水提取物以及萜烯和类黄酮等生物化合物脱颖而出。对活性氧的抗氧化活性是最常被引用的。结论:本研究鉴定出具有较高抗利什曼原虫活性的萜类和类黄酮分子(IC50为2 μM或10 μg/mL, SI为1);这些发现为新世界的社区将植物作为治疗皮肤利什曼病的治疗来源的传统用途提供了科学依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.00
自引率
20.00%
发文量
0
审稿时长
8 weeks
期刊介绍: The Journal of Pharmacy & Pharmacognosy Research (JPPRes) is an international, specialized and peer-reviewed open access journal, under the auspices of AVAGAX – Diseño, Publicidad y Servicios Informáticos, which publishes studies in the pharmaceutical and herbal fields concerned with the physical, botanical, chemical, biological, toxicological properties and clinical applications of molecular entities, active pharmaceutical ingredients, devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture, evaluation and marketing. This journal publishes research papers, reviews, commentaries and letters to the editor as well as special issues and review of pre-and post-graduate thesis from pharmacists or professionals involved in Pharmaceutical Sciences or Pharmacognosy.
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