Application of molecular biology in the detection of human papillomavirus

Abstract

Human papillomavirus (HPV) is the oncogenic virus and is the etiological factor for the genesis of the cervical cancer as well as other squamous cell carcinoma. The evaluation of cervical cancer is mainly diagnosed through cervical cytology, as well as through application of p16 immunohistochemistry. Molecular biology revolutionized the detection of HPV from nucleic acid hybridization to nucleic acid amplification techniques. The present study reviews about the application of molecular biology in the detection of HPV along with its merits and demerits.