Association of rs6323 with neuropsychiatric disorders: a mini-review

Abstract

A data mining analysis was conducted on the National Center for Biotechnology Information database to identify the most extensively studied single-nucleotide variant within the MAO-A gene, which encodes monoamine oxidase A—an enzyme found in mitochondria involved in metabolizing neurotransmitters such as dopamine, norepinephrine, and serotonin. These neurochemicals play crucial roles in the development of various neuropsychiatric disorders. The analysis revealed that the single-nucleotide variant rs6323 has been the subject of significant research concerning its association with human neuropsychiatric disorders and behavioral problems. A thorough literature review was performed, examining original research articles linked to PubMed to evaluate the connection between rs6323 and different neuropsychiatric disorders and behavioral attributes. Multiple studies on diverse ethnic populations across various countries have reported a link between rs6323 and neuropsychiatric disorders and related behavioral characteristics. This review provides valuable insights into the association between rs6323 and neuropsychiatric disorders.